Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73254
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dc.contributor.authorHernáez, Álvaroen_US
dc.contributor.authorSoria-Florido, Maria Trinidaden_US
dc.contributor.authorCastañer, Olgaen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorAlonso-Gómez, Ángelen_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorSchröder, Helmuten_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGomez-Gracia, Enriqueen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorLassale, Camilleen_US
dc.date.accessioned2020-06-15T07:45:46Z-
dc.date.available2020-06-15T07:45:46Z-
dc.date.issued2021en_US
dc.identifier.issn2047-4873en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/73254-
dc.description.abstractPhysical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Preventive Cardiologyen_US
dc.sourceEuropean Journal of Preventive Cardiology [ISSN 2047-4873], v. 28(12), p. 1392–140, (Noviembre 2021)1en_US
dc.subject320501 Cardiologíaen_US
dc.subject.otherBiomarkersen_US
dc.subject.otherHdl Functionen_US
dc.subject.otherLifestyleen_US
dc.subject.otherPhysical Activityen_US
dc.titleLeisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typearticleen_US
dc.identifier.doi10.1177/2047487320925625en_US
dc.identifier.scopus85085877354-
dc.contributor.authorscopusid55916184000-
dc.contributor.authorscopusid57202252585-
dc.contributor.authorscopusid36487707800-
dc.contributor.authorscopusid57214783328-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid35280719100-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid35798512000-
dc.identifier.eissn2047-4881-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.observacionesThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Beatriu de Pinós postdoctoral programme of the Government of Catalonia’s Secretariat for Universities and Research of the Ministry of Economy and Knowledge (2017-BP-00021), Agència de Gestió d’Ajuts Universitaris i de Recerca AGAUR (2014-SGR-240, 2017-SGR-222, 2015-FI_B-01042) and the Instituto de Salud Carlos III (CB06/03/0028, CD17/00122, CES12/025, JR14/00008, PI11/01647 and PI15/00047). The CIBEROBN and CIBERESP are an initiative of the Instituto de Salud Carlos III, which is supported by FEDER funds.en_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,689
dc.description.jcr8,526
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,5
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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