Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/73254
DC Field | Value | Language |
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dc.contributor.author | Hernáez, Álvaro | en_US |
dc.contributor.author | Soria-Florido, Maria Trinidad | en_US |
dc.contributor.author | Castañer, Olga | en_US |
dc.contributor.author | Pintó, Xavier | en_US |
dc.contributor.author | Estruch, Ramón | en_US |
dc.contributor.author | Salas-Salvadó, Jordi | en_US |
dc.contributor.author | Corella, Dolores | en_US |
dc.contributor.author | Alonso-Gómez, Ángel | en_US |
dc.contributor.author | Martínez-González, Miguel Ángel | en_US |
dc.contributor.author | Schröder, Helmut | en_US |
dc.contributor.author | Ros, Emilio | en_US |
dc.contributor.author | Serra Majem, Luis | en_US |
dc.contributor.author | Fiol, Miquel | en_US |
dc.contributor.author | Lapetra, José | en_US |
dc.contributor.author | Gomez-Gracia, Enrique | en_US |
dc.contributor.author | Fitó, Montserrat | en_US |
dc.contributor.author | Lassale, Camille | en_US |
dc.date.accessioned | 2020-06-15T07:45:46Z | - |
dc.date.available | 2020-06-15T07:45:46Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 2047-4873 | en_US |
dc.identifier.other | Scopus | - |
dc.identifier.uri | http://hdl.handle.net/10553/73254 | - |
dc.description.abstract | Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | European Journal of Preventive Cardiology | en_US |
dc.source | European Journal of Preventive Cardiology [ISSN 2047-4873], v. 28(12), p. 1392–140, (Noviembre 2021)1 | en_US |
dc.subject | 320501 Cardiología | en_US |
dc.subject.other | Biomarkers | en_US |
dc.subject.other | Hdl Function | en_US |
dc.subject.other | Lifestyle | en_US |
dc.subject.other | Physical Activity | en_US |
dc.title | Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1177/2047487320925625 | en_US |
dc.identifier.scopus | 85085877354 | - |
dc.contributor.authorscopusid | 55916184000 | - |
dc.contributor.authorscopusid | 57202252585 | - |
dc.contributor.authorscopusid | 36487707800 | - |
dc.contributor.authorscopusid | 57214783328 | - |
dc.contributor.authorscopusid | 7005989830 | - |
dc.contributor.authorscopusid | 7003357665 | - |
dc.contributor.authorscopusid | 7003570538 | - |
dc.contributor.authorscopusid | 7004308784 | - |
dc.contributor.authorscopusid | 7004290629 | - |
dc.contributor.authorscopusid | 35280719100 | - |
dc.contributor.authorscopusid | 35474202600 | - |
dc.contributor.authorscopusid | 35596972100 | - |
dc.contributor.authorscopusid | 7005315313 | - |
dc.contributor.authorscopusid | 6507771144 | - |
dc.contributor.authorscopusid | 57202571697 | - |
dc.contributor.authorscopusid | 6602891390 | - |
dc.contributor.authorscopusid | 35798512000 | - |
dc.identifier.eissn | 2047-4881 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.observaciones | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Beatriu de Pinós postdoctoral programme of the Government of Catalonia’s Secretariat for Universities and Research of the Ministry of Economy and Knowledge (2017-BP-00021), Agència de Gestió d’Ajuts Universitaris i de Recerca AGAUR (2014-SGR-240, 2017-SGR-222, 2015-FI_B-01042) and the Instituto de Salud Carlos III (CB06/03/0028, CD17/00122, CES12/025, JR14/00008, PI11/01647 and PI15/00047). The CIBEROBN and CIBERESP are an initiative of the Instituto de Salud Carlos III, which is supported by FEDER funds. | en_US |
dc.utils.revision | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 1,689 | |
dc.description.jcr | 8,526 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
dc.description.miaricds | 10,5 | |
item.fulltext | Con texto completo | - |
item.grantfulltext | open | - |
crisitem.author.dept | GIR IUIBS: Nutrición | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0002-9658-9061 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Serra Majem, Luis | - |
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