Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73254
Title: Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study
Authors: Hernáez, Álvaro
Soria-Florido, Maria Trinidad
Castañer, Olga
Pintó, Xavier
Estruch, Ramón
Salas-Salvadó, Jordi
Corella, Dolores
Alonso-Gómez, Ángel
Martínez-González, Miguel Ángel
Schröder, Helmut
Ros, Emilio
Serra Majem, Luis 
Fiol, Miquel
Lapetra, José
Gomez-Gracia, Enrique
Fitó, Montserrat
Lassale, Camille
UNESCO Clasification: 320501 Cardiología
Keywords: Biomarkers
Hdl Function
Lifestyle
Physical Activity
Issue Date: 2020
Journal: European Journal Of Preventive Cardiology
Abstract: Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
URI: http://hdl.handle.net/10553/73254
ISSN: 2047-4873
DOI: 10.1177/2047487320925625
Source: European Journal of Preventive Cardiology [ISSN 2047-4873], (Enero 2020)
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