Please use this identifier to cite or link to this item:
Title: Lxr Signaling Regulates Macrophage Survival and Phenotype Polarization Response To Ionizing Radiation
Authors: Lara Jimenez, P. C.
Tabraue, C. 
Mirecki, M.
De La Rosa, J. V. 
López Blanco, Félix 
Bosca, L.
Fernandez, L. 
Castrillo, A.
UNESCO Clasification: 320111 Radiología
Keywords: Macrophages
Issue Date: 2019
Journal: Radiotherapy and Oncology 
Conference: 38th Annual Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO) 
Abstract: Macrophages are a major cellular component of murine and human tumors, where they are commonly termed tumor-associated macrophages (TAMs). Recent studies indicate that ionizing radiation not only polarizes macrophages towards a M1-like phenotype leading an effective antitumor response, but also decreases macrophage survival through a pyroptosis mechanism.The purpose of this study was to evaluate the role of LXR in the response of macrophages to irradiation, analyzing both cell viability and functional activity of the macrophage, as a possiblestrategy focused to deplete TAMs or re-program them towards a M1-like phenotype, in the context of cancer treatment with radiotherapy.
ISSN: 0167-8140
Source: Radiotherapy And Oncology [ISSN 0167-8140], v. 133 sup. 1, p. S74-S75
Appears in Collections:Actas de congresos
Adobe PDF (291,41 kB)
Show full item record

Google ScholarTM



Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.