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Title: Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
Authors: Montull, Beatriz
Menéndez, Rosario
Torres, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martin-Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe Carlos B. 
Rello, Jordi
Molinos, Luis
Ruiz-Manzano, Juan
Aspa, Javier
Editors: Yende, Sachin
UNESCO Clasification: 3207 Patología
Keywords: Severe sepsis
Issue Date: 2016
Journal: PLoS ONE 
Abstract: Background: Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective: To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results: We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07-1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50-2.04) and renal disease (OR, 1.57; 95% CI, 1.21-2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52-0.73). Bacteremia (OR, 1.37; 95% CI, 1.05-1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31-1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10-2.49) were associated with severe sepsis CAP. Conclusions: CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0145929
Source: PLoS ONE [ISSN 1932-6203], v. 11 (1), e0145929
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