Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/70037
Título: Mean platelet volume and major adverse cardiovascular events in congenital heart disease patients
Autores/as: Martínez-Quintana, Efrén 
Rodríguez-Hernández, Juan Lizandro
Riaño-Ruiz, Marta
Rodríguez-González, Fayna
Clasificación UNESCO: 320501 Cardiología
Palabras clave: Congenital Heart Disease
Heart Failure
Inflammation
Mean Platelet Volume
Fecha de publicación: 2019
Publicación seriada: Clinical Hemorheology and Microcirculation 
Resumen: BACKGROUND: Platelet activation is linked with thrombosis, inflammation or heart failure. OBJECTIVE: To establish clinical and analytical factors that may favor high mean platelet volume (MPV) and to determine if MPV levels favor major adverse cardiovascular events (MACE). METHODS: Stable CHD patients and a control population matched for age, sex and cardiovascular factors. RESULTS: 658 CHD patients and 2092 controls were studied. Median age in CHD patients was 33 (25-41) year old with 56% of them being male. No significant differences were seen between MPV values and cardiac complexity (p = 0.308) nor between MPV values in the CHD and control groups (p = 0.911). CHD patients had significant lower platelet count and MPV levels than patients in the control group. In the binary logistic regression analysis NT-pro-BNP levels above 125 pg/ml, thrombocytopenia and having atrial fibrillation/flutter reached statistical significance as predictors of MPV levels above 11 fL. The Kaplan-Meier survival analysis showed no significance between MPV levels higher than 11 fL and MACE, cardiovascular mortality and thrombotic events in a median time follow-up of 6.7(1.5-10.6) years. CONCLUSIONS: Atrial fibrillation/flutter, heart failure and thrombocytopenia are predictors of high MPV levels. A MPV above 11 fL is not associated with MACE at a median follow-up time.
URI: http://hdl.handle.net/10553/70037
ISSN: 1386-0291
DOI: 10.3233/CH-180471
Fuente: Clinical Hemorheology and Microcirculation [ISSN 1386-0291], v. 72 (4), p. 327-337
Colección:Artículos
Vista completa

Citas SCOPUSTM   

3
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

1
actualizado el 25-feb-2024

Visitas

57
actualizado el 24-feb-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.