Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/70037
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dc.contributor.authorMartínez-Quintana, Efrénen_US
dc.contributor.authorRodríguez-Hernández, Juan Lizandroen_US
dc.contributor.authorRiaño-Ruiz, Martaen_US
dc.contributor.authorRodríguez-González, Faynaen_US
dc.date.accessioned2020-02-05T12:52:03Z-
dc.date.available2020-02-05T12:52:03Z-
dc.date.issued2019en_US
dc.identifier.issn1386-0291en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/70037-
dc.description.abstractBACKGROUND: Platelet activation is linked with thrombosis, inflammation or heart failure. OBJECTIVE: To establish clinical and analytical factors that may favor high mean platelet volume (MPV) and to determine if MPV levels favor major adverse cardiovascular events (MACE). METHODS: Stable CHD patients and a control population matched for age, sex and cardiovascular factors. RESULTS: 658 CHD patients and 2092 controls were studied. Median age in CHD patients was 33 (25-41) year old with 56% of them being male. No significant differences were seen between MPV values and cardiac complexity (p = 0.308) nor between MPV values in the CHD and control groups (p = 0.911). CHD patients had significant lower platelet count and MPV levels than patients in the control group. In the binary logistic regression analysis NT-pro-BNP levels above 125 pg/ml, thrombocytopenia and having atrial fibrillation/flutter reached statistical significance as predictors of MPV levels above 11 fL. The Kaplan-Meier survival analysis showed no significance between MPV levels higher than 11 fL and MACE, cardiovascular mortality and thrombotic events in a median time follow-up of 6.7(1.5-10.6) years. CONCLUSIONS: Atrial fibrillation/flutter, heart failure and thrombocytopenia are predictors of high MPV levels. A MPV above 11 fL is not associated with MACE at a median follow-up time.en_US
dc.languageengen_US
dc.relation.ispartofClinical Hemorheology and Microcirculationen_US
dc.sourceClinical Hemorheology and Microcirculation [ISSN 1386-0291], v. 72 (4), p. 327-337en_US
dc.subject320501 Cardiologíaen_US
dc.subject.otherCongenital Heart Diseaseen_US
dc.subject.otherHeart Failureen_US
dc.subject.otherInflammationen_US
dc.subject.otherMean Platelet Volumeen_US
dc.titleMean platelet volume and major adverse cardiovascular events in congenital heart disease patientsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3233/CH-180471
dc.identifier.scopus85073086217-
dc.identifier.isi000488082600001
dc.contributor.authorscopusid23485891800-
dc.contributor.authorscopusid57193055539-
dc.contributor.authorscopusid35811047900-
dc.contributor.authorscopusid24825586600-
dc.description.lastpage337-
dc.identifier.issue4-
dc.description.firstpage327-
dc.relation.volume72-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid614797
dc.contributor.daisngid1386542
dc.contributor.daisngid5971737
dc.contributor.daisngid648988
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Martinez-Quintana, E
dc.contributor.wosstandardWOS:Rodriguez-Hernandez, JL
dc.contributor.wosstandardWOS:Riano-Ruiz, M
dc.contributor.wosstandardWOS:Rodriguez-Gonzalez, F
dc.date.coverdate2019
dc.identifier.ulpgces
dc.description.sjr0,523
dc.description.jcr1,741
dc.description.sjrqQ2
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.fullNameMartínez Quintana, Efrén-
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