Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/70004
Título: Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines in chronic kidney disease: A clinical approach
Autores/as: Oliva-Damaso, Elena
Oliva-Damaso, Nestor
Rodríguez Esparragón, Francisco Javier 
Payan, Juan
Baamonde-Laborda, Eduardo
Gonzalez-Cabrera, Fayna
Santana-Estupiñan, Raquel
Rodríguez Pérez, José Carlos 
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: ADMA
Asymmetric Dimethylarginine
Cardiovascular
Chronic Kidney Disease
End-Stage Renal Disease, et al.
Fecha de publicación: 2019
Publicación seriada: International Journal of Molecular Sciences 
Resumen: Asymmetric dimethylarginine (ADMA) and its enantiomer, Symmetric dimethylarginine (SDMA), are naturally occurring amino acids that were first isolated and characterized in human urine in 1970. ADMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). ADMA has shown to be a significant predictor of cardiovascular outcome and mortality among dialysis patients. On the other hand, although initially SDMA was thought to be an innocuous molecule, we now know that it is an outstanding marker of renal function both in human and in animal models, with ESRD patients on dialysis showing the highest SDMA levels. Today, we know that ADMA and SDMA are not only uremic toxins but also independent risk markers for mortality and cardiovascular disease (CVD). In this review, we summarize the role of both ADMA and SDMA in chronic kidney disease along with other cardiovascular risk factors.
URI: http://hdl.handle.net/10553/70004
ISSN: 1422-0067
DOI: 10.3390/ijms20153668
Fuente: International Journal of Molecular Sciences [ISSN 1422-0067], v. 20 (15), 3668, (Agosto 2019)
Colección:Artículos
miniatura
Adobe PDF (840,69 kB)
Vista completa

Citas SCOPUSTM   

72
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

64
actualizado el 25-feb-2024

Visitas

120
actualizado el 23-mar-2024

Descargas

216
actualizado el 23-mar-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.