Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70004
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dc.contributor.authorOliva-Damaso, Elenaen_US
dc.contributor.authorOliva-Damaso, Nestoren_US
dc.contributor.authorRodríguez Esparragón, Francisco Javieren_US
dc.contributor.authorPayan, Juanen_US
dc.contributor.authorBaamonde-Laborda, Eduardoen_US
dc.contributor.authorGonzalez-Cabrera, Faynaen_US
dc.contributor.authorSantana-Estupiñan, Raquelen_US
dc.contributor.authorRodríguez Pérez, José Carlosen_US
dc.date.accessioned2020-02-05T12:51:52Z-
dc.date.available2020-02-05T12:51:52Z-
dc.date.issued2019en_US
dc.identifier.issn1422-0067en_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/70004-
dc.description.abstractAsymmetric dimethylarginine (ADMA) and its enantiomer, Symmetric dimethylarginine (SDMA), are naturally occurring amino acids that were first isolated and characterized in human urine in 1970. ADMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). ADMA has shown to be a significant predictor of cardiovascular outcome and mortality among dialysis patients. On the other hand, although initially SDMA was thought to be an innocuous molecule, we now know that it is an outstanding marker of renal function both in human and in animal models, with ESRD patients on dialysis showing the highest SDMA levels. Today, we know that ADMA and SDMA are not only uremic toxins but also independent risk markers for mortality and cardiovascular disease (CVD). In this review, we summarize the role of both ADMA and SDMA in chronic kidney disease along with other cardiovascular risk factors.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.sourceInternational Journal of Molecular Sciences [ISSN 1422-0067], v. 20 (15), 3668, (Agosto 2019)en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherADMAen_US
dc.subject.otherAsymmetric Dimethylarginineen_US
dc.subject.otherCardiovascularen_US
dc.subject.otherChronic Kidney Diseaseen_US
dc.subject.otherEnd-Stage Renal Diseaseen_US
dc.subject.otherMethylargininesen_US
dc.subject.otherSDMAen_US
dc.subject.otherSymmetric Dimethylarginineen_US
dc.subject.otherUremiaen_US
dc.titleAsymmetric (ADMA) and symmetric (SDMA) dimethylarginines in chronic kidney disease: A clinical approachen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms20153668en_US
dc.identifier.scopus85070749969-
dc.identifier.isi000482383000061-
dc.contributor.authorscopusid54405943800-
dc.contributor.authorscopusid57188993572-
dc.contributor.authorscopusid6603262370-
dc.contributor.authorscopusid57188994287-
dc.contributor.authorscopusid6504545615-
dc.contributor.authorscopusid12771664100-
dc.contributor.authorscopusid54406451400-
dc.contributor.authorscopusid7005446255-
dc.identifier.eissn1422-0067-
dc.identifier.issue15-
dc.relation.volume20en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid31524669-
dc.contributor.daisngid10499394-
dc.contributor.daisngid30233033-
dc.contributor.daisngid30434120-
dc.contributor.daisngid23673344-
dc.contributor.daisngid5539868-
dc.contributor.daisngid11934294-
dc.contributor.daisngid4337946-
dc.description.notasThis article belongs to the Section Molecular Pathology, Diagnostics, and Therapeuticsen_US
dc.description.numberofpages15en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Oliva-Damaso, E-
dc.contributor.wosstandardWOS:Oliva-Damaso, N-
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, F-
dc.contributor.wosstandardWOS:Payan, J-
dc.contributor.wosstandardWOS:Baamonde-Laborda, E-
dc.contributor.wosstandardWOS:Gonzalez-Cabrera, F-
dc.contributor.wosstandardWOS:Santana-Estupinan, R-
dc.contributor.wosstandardWOS:Rodriguez-Perez, JC-
dc.date.coverdateAgosto 2019en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,317
dc.description.jcr4,556
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameRodríguez Pérez, José Carlos-
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