Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70004
Title: Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines in chronic kidney disease: A clinical approach
Authors: Oliva-Damaso, Elena
Oliva-Damaso, Nestor
Rodríguez Esparragón, Francisco Javier 
Payan, Juan
Baamonde-Laborda, Eduardo
Gonzalez-Cabrera, Fayna
Santana-Estupiñan, Raquel
Rodríguez Pérez, José Carlos 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Adma
Asymmetric Dimethylarginine
Cardiovascular
Chronic Kidney Disease
End-Stage Renal Disease
Methylarginines
Sdma
Symmetric Dimethylarginine
Uremia
Issue Date: 2019
Journal: International Journal of Molecular Sciences 
Abstract: Asymmetric dimethylarginine (ADMA) and its enantiomer, Symmetric dimethylarginine (SDMA), are naturally occurring amino acids that were first isolated and characterized in human urine in 1970. ADMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). ADMA has shown to be a significant predictor of cardiovascular outcome and mortality among dialysis patients. On the other hand, although initially SDMA was thought to be an innocuous molecule, we now know that it is an outstanding marker of renal function both in human and in animal models, with ESRD patients on dialysis showing the highest SDMA levels. Today, we know that ADMA and SDMA are not only uremic toxins but also independent risk markers for mortality and cardiovascular disease (CVD). In this review, we summarize the role of both ADMA and SDMA in chronic kidney disease along with other cardiovascular risk factors.
URI: http://hdl.handle.net/10553/70004
ISSN: 1661-6596
DOI: 10.3390/ijms20153668
Source: International Journal of Molecular Sciences [ISSN 1661-6596], v. 20 (15)
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