Please use this identifier to cite or link to this item:
Title: Diagnostic performance of contrast-enhanced dual-energy spectral mammography (CESM): a retrospective study involving 644 breast lesions
Authors: Travieso-Aja, María del Mar
Maldonado-Saluzzi, Daniel
Naranjo-Santana, Pedro
Fernández-Ruiz, Claudia
Severino-Rondón, Wilsa
Rodríguez Rodríguez, Mario
Vega Benítez, Víctor Manuel 
Pérez-Luzardo, Octavio 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Breast Cancer
Breast Ultrasound
Contrast-Enhanced Dual-Energy Spectral Mammography (Cesm)
Digital Mammography
Iodinated Contrast Medium
Issue Date: 2019
Journal: Radiologia Medica 
Abstract: Objective: To evaluate the diagnostic performance of contrast-enhanced dual-energy spectral mammography (CESM) in comparison with that of full-field digital mammography (FFDM), either alone or accompanied with breast ultrasound (BUS) in a large series of patients/breast lesions (n = 644). Patients and methods: In this retrospective study, five radiologists evaluated the lesions by three imaging modalities: FFDM, FFDM + BUS, and CESM and compared the imaging to the gold standard (histopathology or clinical follow-up). Diagnostic performance parameters and receiver operating characteristic (ROC) curves of CESM were calculated and compared to those of FFDM or FFDM + BUS (McNemar’s test). Additionally, the reliability of tumor size measurement by CESM was compared with the histopathological measurement. Results: The study included 218 benign and 426 malignant lesions. 85% of benign and 93% of malignant lesions were adequately identified using CESM. With respect to FFDM and FFDM + BUS, CESM significantly increased sensitivity to 93.2% (+ 10.7% and + 3.4%, respectively); specificity to 84.4% (+ 15.8% and + 1.7%, respectively); PPV to 92.3% (+ 26.8% and + 3.6%, respectively); NPV to 86.0% (+ 1.6% and + 1.8%, respectively); and accuracy to 90.2% (+ 15.8% and + 3.2%, respectively). In the ROC curves analyses, the comparison among the three AUC values was also statistically significant (p < 0.001). Good agreement between tumor diameters measured using CESM and histopathology was observed (Spearman’s rank correlation, r = 0.891, p < 0.0001), although this technique tended to produce an overestimation of the size (+ 7 mm). Conclusions: CESM has high diagnostic accuracy and can be considered as a useful technique for the assessment of breast lesions.
ISSN: 0033-8362
DOI: 10.1007/s11547-019-01056-2
Source: Radiologia Medica [ISSN 0033-8362], v. 124 (10), p. 1006-1017
Appears in Collections:Artículos
Show full item record


checked on May 28, 2023


checked on Oct 2, 2022

Page view(s)

checked on Feb 4, 2023

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.