|Title:||Subjective Cognitive Decline below and above the Age of 60: A Multivariate Study on Neuroimaging, Cognitive, Clinical, and Demographic Measures||Authors:||Cedres, Nira
Hernández-Cabrera, Juan Andres
Subjective Cognitive Decline, et al
|Issue Date:||2019||Journal:||Journal of Alzheimer's Disease||Abstract:||© 2019 - IOS Press and the authors. All rights reserved. Subjective cognitive complaints in cognitively normal individuals are a relevant predictor of Alzheimer's disease (AD), cerebrovascular disease, and age-related tauopathy. Complaints starting after the age of 60 increase the likelihood of preclinical AD. However, this criterion is arbitrary and current data show that neurodegenerative disorders likely start before that age. Further, data on the role of subjective complaints below the age of 60 in individuals qualifying for subjective cognitive decline (SCD) are lacking. We investigated the association of subjective cognitive complaints with an extensive number of neuroimaging, demographic, clinical, and cognitive measures in individuals fulfilling criteria for SCD below and above the age of 60. Nine complaints were scored in 416 individuals. Complaints were related to a higher load of white matter signal abnormalities, and this association was stronger the more subclinical changes in personality, interest, and drive were reported. In individuals <60 years, complaints were associated with lower global cognitive performance. In individuals ≥60 years, complaints were related to greater global brain atrophy and smaller total intracranial volume, and this association was stronger the more subclinical difficulties in activities of daily living were reported. Also, complaints were associated with increased depressive symptomatology irrespective of age. We conclude that complaints below the age of 60 may be associated with subtle signs of brain pathology. In the community, screening for risk of future cognitive decline should include subjective cognitive complaints, depressive symptomatology, and subclinical reduced cognition (<60 years)/activities of daily living (≥60 years), supported by basic neuroimaging examinations.||URI:||http://hdl.handle.net/10553/69840||ISSN:||1387-2877||DOI:||10.3233/JAD-180720||Source:||Journal of Alzheimer's Disease[ISSN 1387-2877],v. 68 (1), p. 295-309|
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