Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69840
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dc.contributor.authorCedres, Niraen_US
dc.contributor.authorMachado, Alejandraen_US
dc.contributor.authorMolina, Yaizaen_US
dc.contributor.authorDiaz-Galvan, Patriciaen_US
dc.contributor.authorHernández-Cabrera, Juan Andresen_US
dc.contributor.authorBarroso, Joseen_US
dc.contributor.authorWestman, Ericen_US
dc.contributor.authorFerreira, Danielen_US
dc.date.accessioned2020-02-05T12:50:38Z-
dc.date.available2020-02-05T12:50:38Z-
dc.date.issued2019en_US
dc.identifier.issn1387-2877en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69840-
dc.description.abstract© 2019 - IOS Press and the authors. All rights reserved. Subjective cognitive complaints in cognitively normal individuals are a relevant predictor of Alzheimer's disease (AD), cerebrovascular disease, and age-related tauopathy. Complaints starting after the age of 60 increase the likelihood of preclinical AD. However, this criterion is arbitrary and current data show that neurodegenerative disorders likely start before that age. Further, data on the role of subjective complaints below the age of 60 in individuals qualifying for subjective cognitive decline (SCD) are lacking. We investigated the association of subjective cognitive complaints with an extensive number of neuroimaging, demographic, clinical, and cognitive measures in individuals fulfilling criteria for SCD below and above the age of 60. Nine complaints were scored in 416 individuals. Complaints were related to a higher load of white matter signal abnormalities, and this association was stronger the more subclinical changes in personality, interest, and drive were reported. In individuals <60 years, complaints were associated with lower global cognitive performance. In individuals ≥60 years, complaints were related to greater global brain atrophy and smaller total intracranial volume, and this association was stronger the more subclinical difficulties in activities of daily living were reported. Also, complaints were associated with increased depressive symptomatology irrespective of age. We conclude that complaints below the age of 60 may be associated with subtle signs of brain pathology. In the community, screening for risk of future cognitive decline should include subjective cognitive complaints, depressive symptomatology, and subclinical reduced cognition (<60 years)/activities of daily living (≥60 years), supported by basic neuroimaging examinations.en_US
dc.languagespaen_US
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.sourceJournal of Alzheimer's Disease[ISSN 1387-2877],v. 68 (1), p. 295-309en_US
dc.subject.otherBrain Atrophyen_US
dc.subject.otherDepressive Symptomatologyen_US
dc.subject.otherMiddle-Ageen_US
dc.subject.otherMultivariateanalysisen_US
dc.subject.otherSubjective Cognitive Declineen_US
dc.subject.otherWhite Matter Signal Abnormalitiesen_US
dc.titleSubjective Cognitive Decline below and above the Age of 60: A Multivariate Study on Neuroimaging, Cognitive, Clinical, and Demographic Measuresen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3233/JAD-180720en_US
dc.identifier.scopus85062829438-
dc.contributor.authorscopusid57207764402-
dc.contributor.authorscopusid55921689200-
dc.contributor.authorscopusid55921001400-
dc.contributor.authorscopusid57207757650-
dc.contributor.authorscopusid34875064600-
dc.contributor.authorscopusid7103318279-
dc.contributor.authorscopusid35070775000-
dc.contributor.authorscopusid55356608800-
dc.description.lastpage309en_US
dc.identifier.issue1-
dc.description.firstpage295en_US
dc.relation.volume68en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgces
dc.description.sjr1,586
dc.description.jcr3,909
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
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