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Title: Assessment of the efficacy of platelet-rich plasma in the treatment of traumatic canine fractures
Authors: López, Sergio
Vilar Guereño, José Manuel 
Sopena, Joaquín J.
Damià, Elena
Chicharro, Deborah
Carrillo, José M.
Cuervo, Belén
Rubio, Mónica
UNESCO Clasification: 310907 Patología
321315 Traumatología
Keywords: Bone Healing
Issue Date: 2019
Journal: International Journal of Molecular Sciences 
Abstract: The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With this objective, sixty-five dogs with radius/ulna or tibia/fibula bone fractures were randomly divided into two groups (PRGF and saline solution (SS) groups) and checked at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180. All the fractures were treated with an external skeletal fixation, and pain was controlled with Carprofen. Healing was evaluated by physical examination, limb function, radiography, and by a Likert-type owner satisfaction questionnaire. A faster fracture healing was observed in the PRGF group, with statistically significant differences with respect to the SS group. Swelling at the fracture site was significantly greater at day 14 and 28 in animals injected with PRGF, and more pain on palpation was found in the area at day 28. The injection of PRGF in acute bone fractures accelerates bone healing.
ISSN: 1661-6596
DOI: 10.3390/ijms20051075
Source: International Journal of Molecular Sciences [ISSN 1661-6596], v. 20 (5), 1075
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