Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69821
Title: Effect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on weight loss and cardiovascular risk factors: One-year results of the PREDIMED-Plus trial
Authors: Salas-Salvadó, Jordi
Díaz-López, Andrés
Ruiz-Canela, Miguel
Basora, Josep
Fitó, Montse
Corella, Dolores
Serra-Majem, Luís 
Wärnberg, Julia
Romaguera, Dora
Estruch, Ramon
Vidal, Josep
Alfredo Martínez, J.
Arós, Fernando
Vázquez, Clotilde
Ros, Emilio
Vioque, Jesús
López-Miranda, José
Bueno-Cavanillas, Aurora
Tur, Josep A.
Tinahones, Francisco J.
Martín, Vicente
Lapetra, José
Pintó, Xavier
Daimiel, Lidia
Delgado-Rodríguez, Miguel
Matía, Pilar
Gómez-Gracia, Enrique
Díez-Espino, Javier
Babio, Nancy
Castañer, Olga
Sorlí, José V.
Fiol, Miquel
Zulet, María Ángeles
Bulló, Mònica
Goday, Albert
Martínez-González, Miguel
Sánchez Villegas, Almudena 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Low-Carbohydrate
Follow-Up
Obesity
Fat
Metaanalysis, et al
Issue Date: 2019
Project: Efecto de la Dieta Mediterránea Hopocalórica y Promoción de la Actividad Física en Prevención Primaria Cardiovascular.Estudio Piloto Sobre Marcadores Intermedios. 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Journal: Diabetes Care 
Abstract: OBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55–75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. RESULTS Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of 22.5 kg (95% CI 23.1 to 21.9). Weight loss ‡5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA1c, and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts. CONCLUSIONS PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.
URI: http://hdl.handle.net/10553/69821
ISSN: 0149-5992
DOI: 10.2337/dc18-0836
Source: Diabetes Care [ISSN 0149-5992], v. 42 (5), p. 777-788
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