Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69821
DC FieldValueLanguage
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorDíaz-López, Andrésen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorBasora, Josepen_US
dc.contributor.authorFitó, Montseen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSerra-Majem, Luísen_US
dc.contributor.authorWärnberg, Juliaen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorVidal, Josepen_US
dc.contributor.authorAlfredo Martínez, J.en_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorVázquez, Clotildeen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorVioque, Jesúsen_US
dc.contributor.authorLópez-Miranda, Joséen_US
dc.contributor.authorBueno-Cavanillas, Auroraen_US
dc.contributor.authorTur, Josep A.en_US
dc.contributor.authorTinahones, Francisco J.en_US
dc.contributor.authorMartín, Vicenteen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorDaimiel, Lidiaen_US
dc.contributor.authorDelgado-Rodríguez, Miguelen_US
dc.contributor.authorMatía, Pilaren_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorDíez-Espino, Javieren_US
dc.contributor.authorBabio, Nancyen_US
dc.contributor.authorCastañer, Olgaen_US
dc.contributor.authorSorlí, José V.en_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorZulet, María Ángelesen_US
dc.contributor.authorBulló, Mònicaen_US
dc.contributor.authorGoday, Alberten_US
dc.contributor.authorMartínez-González, Miguelen_US
dc.contributor.authorSánchez Villegas, Almudenaen_US
dc.contributor.authorBautista Castaño, Inmaculadaen_US
dc.date.accessioned2020-02-05T12:50:22Z-
dc.date.available2020-02-05T12:50:22Z-
dc.date.issued2019en_US
dc.identifier.issn0149-5992en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69821-
dc.description.abstractOBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55–75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. RESULTS Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of 22.5 kg (95% CI 23.1 to 21.9). Weight loss ‡5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA1c, and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts. CONCLUSIONS PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.en_US
dc.languageengen_US
dc.relationEfecto de la Dieta Mediterránea Hopocalórica y Promoción de la Actividad Física en Prevención Primaria Cardiovascular.Estudio Piloto Sobre Marcadores Intermedios.en_US
dc.relationEfecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascularen_US
dc.relation.ispartofDiabetes Careen_US
dc.sourceDiabetes Care [ISSN 0149-5992], v. 42 (5), p. 777-788en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherLow-Carbohydrateen_US
dc.subject.otherFollow-Upen_US
dc.subject.otherObesityen_US
dc.subject.otherFaten_US
dc.subject.otherMetaanalysisen_US
dc.subject.otherOverweighten_US
dc.subject.otherInterleukin-18en_US
dc.subject.otherIndividualsen_US
dc.subject.otherResistanceen_US
dc.subject.otherBenefitsen_US
dc.titleEffect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on weight loss and cardiovascular risk factors: One-year results of the PREDIMED-Plus trialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.2337/dc18-0836en_US
dc.identifier.scopus85062162906-
dc.identifier.isi000465238900018-
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dc.identifier.eissn1935-5548-
dc.description.lastpage788en_US
dc.identifier.issue5-
dc.description.firstpage777en_US
dc.relation.volume42en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Diaz-Lopez, A-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Basora, J-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Warnberg, J-
dc.contributor.wosstandardWOS:Romaguera, D-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Vidal, J-
dc.contributor.wosstandardWOS:Martinez, JA-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Vazquez, C-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Vioque, J-
dc.contributor.wosstandardWOS:Lopez-Miranda, J-
dc.contributor.wosstandardWOS:Bueno-Cavanillas, A-
dc.contributor.wosstandardWOS:Tur, JA-
dc.contributor.wosstandardWOS:Tinahones, FJ-
dc.contributor.wosstandardWOS:Martin, V-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Pinto, X-
dc.contributor.wosstandardWOS:Daimiel, L-
dc.contributor.wosstandardWOS:Delgado-Rodriguez, M-
dc.contributor.wosstandardWOS:Matia, P-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.contributor.wosstandardWOS:Diez-Espino, J-
dc.contributor.wosstandardWOS:Babio, N-
dc.contributor.wosstandardWOS:Castaner, O-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Zulet, MA-
dc.contributor.wosstandardWOS:Bullo, M-
dc.contributor.wosstandardWOS:Goday, A-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.date.coverdateMayo 2019en_US
dc.identifier.ulpgcen_US
dc.description.jcr16,019
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.orcid0000-0001-7733-9238-
crisitem.author.orcid0000-0001-9257-8739-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.author.fullNameSánchez Villegas,Almudena-
crisitem.author.fullNameBautista Castaño, Inmaculada-
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