Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/69321
Título: Polycaprolactone-carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion
Autores/as: Alemán-Domínguez, M. E. 
Ortega, Z. 
Benitez, A. N. 
Monzón, Mario 
Garzon, L., V
Ajami, Sara
Liu, Chaozong
Clasificación UNESCO: 3303 ingeniería y tecnología químicas
Palabras clave: Fiber-Deposited Scaffolds
Mechanical-Properties
In-Vitro
Biomaterials
Behavior, et al.
Fecha de publicación: 2018
Publicación seriada: Bio-design and manufacturing 
Resumen: Polycaprolactone-carboxymethyl cellulose composites have been obtained and used to print porous structures by material extrusion. The materials used contained 0, 2 and 5% w/w of the carboxymethyl cellulose additive. These structures have been analyzed in terms of their morphology (including the evaluation of their porosity), mechanical properties under compression load and cell affinity. Cell affinity has been evaluated by culturing sheep mesenchymal stem cells and analyzing their viability by the Alamar Blue (R) assay at days 1, 3, 6 and 8. The results show that composites samples have similar values of porosity and apparent density than pure polycaprolactone ones. However, samples containing 5% w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition process. This characteristic affects the mechanical properties of the structures, so these ones have a mean compression modulus significantly lower than pure polycaprolactone scaffolds. However, the samples containing 2% w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone ones in terms of their mechanical properties. Moreover, the presence of 2% w/w of additive improves cell proliferation on the surface of the porous structures. As complementary information, the flow properties of the composite materials were studied and the power law equations at 210 degrees C obtained, as this temperature was the 3D printing temperature. These equations can be useful for simulation and designing purposes of other manufacturing processes.
URI: http://hdl.handle.net/10553/69321
ISSN: 2096-5524
DOI: 10.1007/s42242-018-0024-z
Fuente: Bio-Design And Manufacturing[ISSN 2096-5524],v. 1 (4), p. 245-253
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