Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/6567
Title: Convective oxygen transport and fatigue
Authors: Amann, Markus
Calbet, Jose A. L. 
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Fatigue
Exercise
Performance
Issue Date: 2008
Journal: Journal of Applied Physiology 
Abstract: During exercise, fatigue is defined as a reversible reduction in force- or power-generating capacity and can be elicited by central and/or peripheral mechanisms. During skeletal muscle contractions, both aspects of fatigue may develop independent of alterations in convective O(2) delivery; however, reductions in O(2) supply exacerbate and increases attenuate the rate of accumulation. In this regard, peripheral fatigue development is mediated via the O(2)-dependent rate of accumulation of metabolic by-products (e.g., inorganic phosphate) and their interference with excitation-contraction coupling within the myocyte. In contrast, the development of O(2)-dependent central fatigue is elicited 1) by interference with the development of central command and/or 2) via inhibitory feedback on central motor drive secondary to the peripheral effects of low convective O(2) transport. Changes in convective O(2) delivery in the healthy human can result from modifications in arterial O(2) content, blood flow, or a combination of both, and they can be induced via heavy exercise even at sea level; these changes are exacerbated during acute and chronic exposure to altitude. This review focuses on the effects of changes in convective O(2) delivery on the development of central and peripheral fatigue.
URI: http://hdl.handle.net/10553/6567
ISSN: 8750-7587
DOI: 10.1152/japplphysiol.01008.2007
Source: Journal Of Applied Physiology[ISSN 8750-7587],v. 104 (3), p. 861-870
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