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Title: Plasma lipidomic profiling and risk of type 2 diabetes in the PREDIMED trial
Authors: Razquin, Cristina
Toledo, Estefanía
Clish, Clary B.
Ruiz-Canela, Miguel
Dennis, Courtney
Corella, Dolores
Papandreou, Christopher
Ros, Emilio
Estruch, Ramon
Guasch-Ferré, Marta
Gómez-Gracia, Enrique
Fitó, Montserrat
Yu, Edward
Lapetra, José
Wang, Dong
Romaguera, Dora
Liang, Liming
Alonso-Gómez, Angel
Deik, Amy
Bullo, Mónica
Serra-Majem, Lluis 
Salas-Salvadó, Jordi
Hu, Frank B.
Martínez-González, Miguel A.
Keywords: Disease
Signature, et al
Issue Date: 2018
Publisher: 0149-5992
Project: Red Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006) 
Journal: Diabetes Care 
Abstract: OBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk.RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence.RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend <0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend <0.001 for all). One-year changes in these lipids showed associations in similar directions but were not significant after adjustment for baseline levels. TAGs with odd-chain fatty acids showed inverse associations with T2D after adjusting for total TAGs.CONCLUSIONSTwo plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
ISSN: 0149-5992
DOI: 10.2337/dc18-0840
Source: Diabetes Care[ISSN 0149-5992],v. 41, p. 2617-2624
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