Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54953
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dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorToledo, Estefaníaen_US
dc.contributor.authorClish, Clary B.en_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorDennis, Courtneyen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorPapandreou, Christopheren_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorYu, Edwarden_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorWang, Dongen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorAlonso-Gómez, Angelen_US
dc.contributor.authorDeik, Amyen_US
dc.contributor.authorBullo, Mónicaen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.date.accessioned2019-02-18T15:52:13Z-
dc.date.available2019-02-18T15:52:13Z-
dc.date.issued2018en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10553/54953-
dc.description.abstractOBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk.RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence.RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend <0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend <0.001 for all). One-year changes in these lipids showed associations in similar directions but were not significant after adjustment for baseline levels. TAGs with odd-chain fatty acids showed inverse associations with T2D after adjusting for total TAGs.CONCLUSIONSTwo plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.en_US
dc.languagespaen_US
dc.publisher0149-5992
dc.relationRed Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006)en_US
dc.relation.ispartofDiabetes Careen_US
dc.sourceDiabetes Care[ISSN 0149-5992],v. 41, p. 2617-2624en_US
dc.subject.otherDisease
dc.subject.otherPhosphatidylcholine
dc.subject.otherDyslipidemia
dc.subject.otherPrevalence
dc.subject.otherSignature
dc.subject.otherMellitus
dc.subject.otherMarkers
dc.subject.otherSerum
dc.titlePlasma lipidomic profiling and risk of type 2 diabetes in the PREDIMED trialen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.2337/dc18-0840en_US
dc.identifier.scopus85056802094-
dc.identifier.isi000450560000030-
dc.contributor.authorscopusid13612519200-
dc.contributor.authorscopusid7003562288-
dc.contributor.authorscopusid35460787900-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid57130114700-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid36470858000-
dc.contributor.authorscopusid57202558933-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid56660312400-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid56351539800-
dc.contributor.authorscopusid8161433300-
dc.contributor.authorscopusid57204812694-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid54880256400-
dc.contributor.authorscopusid57194127916-
dc.contributor.authorscopusid57202560799-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid36038688700-
dc.contributor.authorscopusid7004290629-
dc.description.lastpage2624en_US
dc.description.firstpage2617en_US
dc.relation.volume41en_US
dc.type2Artículoen_US
dc.contributor.daisngid845551-
dc.contributor.daisngid140645-
dc.contributor.daisngid84840-
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dc.contributor.daisngid34937322-
dc.contributor.daisngid1288250-
dc.contributor.daisngid232668-
dc.contributor.daisngid104058-
dc.contributor.daisngid28220288-
dc.contributor.daisngid1279688-
dc.contributor.daisngid167315-
dc.contributor.daisngid28836-
dc.contributor.daisngid25605-
dc.contributor.daisngid276-
dc.contributor.daisngid17754-
dc.contributor.wosstandardWOS:Razquin, C-
dc.contributor.wosstandardWOS:Toledo, E-
dc.contributor.wosstandardWOS:Clish, CB-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Dennis, C-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Papandreou, C-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Guasch-Ferre, M-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Yu, E-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Wang, D-
dc.contributor.wosstandardWOS:Romaguera, D-
dc.contributor.wosstandardWOS:Liang, LM-
dc.contributor.wosstandardWOS:Alonso-Gomez, A-
dc.contributor.wosstandardWOS:Deik, A-
dc.contributor.wosstandardWOS:Bullo, M-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Hu, FB-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.date.coverdateDiciembre 2018en_US
dc.identifier.ulpgces
dc.description.sjr6,085
dc.description.jcr15,27
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
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