Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Title:	Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities
Authors:	Triana, Jorge Eiroa, José Luis Ortega, Juan José León, Francisco Brouard Martín,Ignacio Torres, Fernando Quintana, José Estévez, Francisco Bermejo, Jaime
UNESCO Clasification:	32 Ciencias médicas 3209 Farmacología
Keywords:	Occurring Terpene Derivatives Pyrethrum Flowers Constituents Eudesmanolides
Issue Date:	2008
Project:	Nuevos Compuestos Antileucémicos Desarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicos INTERREG IIIB Azores-Madeira-Canarias (04/MAC/3.5/C5)
Journal:	Journal of Natural Products
Abstract:	Four new sesquiterpene lactones (1−4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).
URI:	http://hdl.handle.net/10553/53536
ISSN:	0163-3864
DOI:	10.1021/np800474v
Source:	Journal of Natural Products [ISSN 0163-3864], v. 71 (12), p. 2015-2020, (Diciembre 2008)
Appears in Collections:	Artículos

Show full item record