Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/53536
Title: Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities
Authors: Triana, Jorge
Eiroa, José Luis 
Ortega, Juan José
León, Francisco
Brouard, Ignacio
Torres, Fernando
Quintana, José 
Estévez, Francisco 
Bermejo, Jaime
UNESCO Clasification: Investigación
Keywords: Occurring Terpene Derivatives
Pyrethrum Flowers
Constituents
Eudesmanolides
Issue Date: 2008
Publisher: 0163-3864
Project: Nuevos Compuestos Antileucémicos 
Desarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicos 
INTERREG IIIB Azores-Madeira-Canarias (04/MAC/3.5/C5)
Journal: Journal of Natural Products 
Abstract: Four new sesquiterpene lactones (1−4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).
URI: http://hdl.handle.net/10553/48432
ISSN: 0163-3864
DOI: 10.1021/np800474v
Source: Journal of Natural Products [ISSN 0163-3864], v. 71 (12), p. 2015-2020
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