|Title:||3 '-Hydroxy-3,4 '-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells||Authors:||Estevez-Sarmiento, Francisco
|UNESCO Clasification:||32 Ciencias médicas
|Issue Date:||2017||Publisher:||0968-0896||Journal:||Bioorganic and Medicinal Chemistry||Abstract:||Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death.||URI:||http://hdl.handle.net/10553/37177||ISSN:||0968-0896||DOI:||10.1016/j.bmc.2017.09.043||Source:||Bioorganic and Medicinal Chemistry [ISSN 0968-0896], v. 25 (21), p. 6060-6070|
|Appears in Collections:||Artículos|
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