Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/53525
Title: 3 '-Hydroxy-3,4 '-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells
Authors: Estévez Sarmiento, Francisco 
Said, Mercedes 
Brouard Martín,Ignacio 
León, Francisco
García, Celina
Quintana, Jose 
Estevez, Francisco 
UNESCO Clasification: 32 Ciencias médicas
320106 Dermatología
Keywords: Apoptosis
Caspases
Cytotoxicity
Flavonoids
Melanoma
Issue Date: 2017
Journal: Bioorganic and Medicinal Chemistry 
Abstract: Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death.
URI: http://hdl.handle.net/10553/53525
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.09.043
Source: Bioorganic and Medicinal Chemistry [ISSN 0968-0896], v. 25 (21), p. 6060-6070, (2017)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

7
checked on Jun 26, 2022

WEB OF SCIENCETM
Citations

7
checked on Jun 26, 2022

Page view(s)

10
checked on Mar 26, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.