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http://hdl.handle.net/10553/53258
| Título: | Histopathological and Immunohistochemical Findings in the Lungs of Pigs Infected Experimentally with Mycoplasma hyopneumoniae | Autores/as: | Redondo, E. Masot, A. J. Fernandez, A. Gazquez, A. |
Palabras clave: | Multisystemic Wasting Syndrome Bronchoalveolar Lavage Fluids Respiratory Syndrome Virus In-Situ Hybridization Proinflammatory Cytokines, et al. |
Fecha de publicación: | 2009 | Editor/a: | 0021-9975 | Publicación seriada: | Journal of Comparative Pathology | Resumen: | Pigs were infected intranasally with Mycoplasma hyopneumoniae and killed at. intervals ranging from 7 to 35 days post-infection (dpi). Histopathological changes consisted of (1) exudates airways and alveolar lumina, (2) peribronchial and peribronchiolar lymphoid hyperplasia, and (3) enlargement of alveolar septa. These changes were particularly marked from 7 to 28 dpi, coinciding with significant increases in the expression, detected immunohistochemically, of cytokines (IL-1 alpha, IL-1 beta, IL-8, TNF-alpha and INF-gamma) and lymphoid markers (CD4+ CD8 +, muramidase, IgG +, IgA+). Both the lesions and immunohistochemical signals declined in intensity, beyond 35 days. (C) 2009 Elsevier Ltd. All rights reserved. | URI: | http://hdl.handle.net/10553/53258 | ISSN: | 0021-9975 | DOI: | 10.1016/j.jcpa.2008.12.008 | Fuente: | Journal Of Comparative Pathology[ISSN 0021-9975],v. 140 (4), p. 260-270 |
| Colección: | Artículos |
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