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Title: Histopathological and Immunohistochemical Findings in the Lungs of Pigs Infected Experimentally with Mycoplasma hyopneumoniae
Authors: Redondo, E.
Masot, A. J.
Fernandez, A. 
Gazquez, A.
Keywords: Multisystemic Wasting Syndrome
Bronchoalveolar Lavage Fluids
Respiratory Syndrome Virus
In-Situ Hybridization
Proinflammatory Cytokines, et al
Issue Date: 2009
Publisher: 0021-9975
Journal: Journal of Comparative Pathology 
Abstract: Pigs were infected intranasally with Mycoplasma hyopneumoniae and killed at. intervals ranging from 7 to 35 days post-infection (dpi). Histopathological changes consisted of (1) exudates airways and alveolar lumina, (2) peribronchial and peribronchiolar lymphoid hyperplasia, and (3) enlargement of alveolar septa. These changes were particularly marked from 7 to 28 dpi, coinciding with significant increases in the expression, detected immunohistochemically, of cytokines (IL-1 alpha, IL-1 beta, IL-8, TNF-alpha and INF-gamma) and lymphoid markers (CD4+ CD8 +, muramidase, IgG +, IgA+). Both the lesions and immunohistochemical signals declined in intensity, beyond 35 days. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2008.12.008
Source: Journal Of Comparative Pathology[ISSN 0021-9975],v. 140 (4), p. 260-270
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