|Title:||Histopathological and Immunohistochemical Findings in the Lungs of Pigs Infected Experimentally with Mycoplasma hyopneumoniae||Authors:||Redondo, E.
Masot, A. J.
|Keywords:||Multisystemic Wasting Syndrome
Bronchoalveolar Lavage Fluids
Respiratory Syndrome Virus
Proinflammatory Cytokines, et al
|Issue Date:||2009||Publisher:||0021-9975||Journal:||Journal of Comparative Pathology||Abstract:||Pigs were infected intranasally with Mycoplasma hyopneumoniae and killed at. intervals ranging from 7 to 35 days post-infection (dpi). Histopathological changes consisted of (1) exudates airways and alveolar lumina, (2) peribronchial and peribronchiolar lymphoid hyperplasia, and (3) enlargement of alveolar septa. These changes were particularly marked from 7 to 28 dpi, coinciding with significant increases in the expression, detected immunohistochemically, of cytokines (IL-1 alpha, IL-1 beta, IL-8, TNF-alpha and INF-gamma) and lymphoid markers (CD4+ CD8 +, muramidase, IgG +, IgA+). Both the lesions and immunohistochemical signals declined in intensity, beyond 35 days. (C) 2009 Elsevier Ltd. All rights reserved.||URI:||http://hdl.handle.net/10553/53258||ISSN:||0021-9975||DOI:||10.1016/j.jcpa.2008.12.008||Source:||Journal Of Comparative Pathology[ISSN 0021-9975],v. 140 (4), p. 260-270|
|Appears in Collections:||Artículos|
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