Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52601
Title: High dietary protein intake is associated with an increased body weight and total death risk
Authors: Hernández-Alonso, Pablo
Salas-Salvadó, Jordi
Ruiz-Canela, Miguel
Corella, Dolores
Estruch, Ramón
Fitó, Montserrat
Arós, Fernando
Gómez-Gracia, Enrique
Fiol, Miguel
Lapetra, José
Basora, Josep
Serra-Majem, L. 
Muñoz, Miguel Ángel
Buil-Cosiales, Pilar
Saiz, Carmen
Bulló, Mònica
UNESCO Clasification: 320610 Enfermedades de la nutrición
Keywords: Body weight
Cardiovascular
Death
Protein
Risk
Issue Date: 2016
Journal: Clinical Nutrition 
Abstract: Background & aims: High dietary protein diets are widely used to manage overweight and obesity. However, there is a lack of consensus about their long-term efficacy and safety. Therefore, the aim of this study was to assess the effect of long-term high-protein consumption on body weight changes and death outcomes in subjects at high cardiovascular risk. Methods: A secondary analysis of the PREDIMED trial was conducted. Dietary protein was assessed using a food-frequency questionnaire during the follow-up. Cox proportional hazard models were used to estimate the multivariate-adjusted hazard ratio (HR) and 95% confidence intervals (95%CI) for protein intake in relation to the risk of body weight and waist circumference changes, cardiovascular disease, cardiovascular death, cancer death and total death. Results: Higher total protein intake, expressed as percentage of energy, was significantly associated with a greater risk of weight gain when protein replaced carbohydrates (HR: 1.90; 95%CI: 1.05, 3.46) but not when replaced fat (HR: 1.69; 95%CI: 0.94, 3.03). However, no association was found between protein intake and waist circumference. Contrary, higher total protein intake was associated with a greater risk of all-cause death in both carbohydrate and fat substitution models (HR: 1.59; 95%CI: 1.08, 2.35; and HR: 1.66; 95%CI: 1.13, 2.43, respectively). A higher consumption of animal protein was associated with an increased risk of fatal and non-fatal outcomes when protein substituted carbohydrates or fat. Conclusions: Higher dietary protein intake is associated with long-term increased risk of body weight gain and overall death in a Mediterranean population at high cardiovascular risk.
URI: http://hdl.handle.net/10553/52601
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2015.03.016
Source: Clinical Nutrition [ISSN 0261-5614], v. 35 (2), p. 496-506
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

37
checked on May 9, 2021

WEB OF SCIENCETM
Citations

33
checked on May 9, 2021

Page view(s)

11
checked on May 9, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.