Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52601
DC FieldValueLanguage
dc.contributor.authorHernández-Alonso, Pabloen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorFiol, Miguelen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorBasora, Josepen_US
dc.contributor.authorSerra-Majem, L.en_US
dc.contributor.authorMuñoz, Miguel Ángelen_US
dc.contributor.authorBuil-Cosiales, Pilaren_US
dc.contributor.authorSaiz, Carmenen_US
dc.contributor.authorBulló, Mònicaen_US
dc.date.accessioned2018-12-04T16:24:41Z-
dc.date.available2018-12-04T16:24:41Z-
dc.date.issued2016en_US
dc.identifier.issn0261-5614en_US
dc.identifier.urihttp://hdl.handle.net/10553/52601-
dc.description.abstractBackground & aims: High dietary protein diets are widely used to manage overweight and obesity. However, there is a lack of consensus about their long-term efficacy and safety. Therefore, the aim of this study was to assess the effect of long-term high-protein consumption on body weight changes and death outcomes in subjects at high cardiovascular risk. Methods: A secondary analysis of the PREDIMED trial was conducted. Dietary protein was assessed using a food-frequency questionnaire during the follow-up. Cox proportional hazard models were used to estimate the multivariate-adjusted hazard ratio (HR) and 95% confidence intervals (95%CI) for protein intake in relation to the risk of body weight and waist circumference changes, cardiovascular disease, cardiovascular death, cancer death and total death. Results: Higher total protein intake, expressed as percentage of energy, was significantly associated with a greater risk of weight gain when protein replaced carbohydrates (HR: 1.90; 95%CI: 1.05, 3.46) but not when replaced fat (HR: 1.69; 95%CI: 0.94, 3.03). However, no association was found between protein intake and waist circumference. Contrary, higher total protein intake was associated with a greater risk of all-cause death in both carbohydrate and fat substitution models (HR: 1.59; 95%CI: 1.08, 2.35; and HR: 1.66; 95%CI: 1.13, 2.43, respectively). A higher consumption of animal protein was associated with an increased risk of fatal and non-fatal outcomes when protein substituted carbohydrates or fat. Conclusions: Higher dietary protein intake is associated with long-term increased risk of body weight gain and overall death in a Mediterranean population at high cardiovascular risk.en_US
dc.languageengen_US
dc.relation.ispartofClinical Nutritionen_US
dc.sourceClinical Nutrition [ISSN 0261-5614], v. 35 (2), p. 496-506en_US
dc.subject320610 Enfermedades de la nutriciónen_US
dc.subject.otherBody weighten_US
dc.subject.otherCardiovascularen_US
dc.subject.otherDeathen_US
dc.subject.otherProteinen_US
dc.subject.otherRisken_US
dc.titleHigh dietary protein intake is associated with an increased body weight and total death risken_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.clnu.2015.03.016
dc.identifier.scopus84960484120
dc.identifier.isi000373865200028
dc.contributor.authorscopusid56239477300
dc.contributor.authorscopusid7003357665
dc.contributor.authorscopusid6603417884
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid57202571697
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid23017786300
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid57207272093
dc.contributor.authorscopusid26029100700
dc.contributor.authorscopusid6602702155
dc.contributor.authorscopusid6602243634
dc.description.lastpage506-
dc.identifier.issue2-
dc.description.firstpage496-
dc.relation.volume35-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2700977
dc.contributor.daisngid25605
dc.contributor.daisngid31761100
dc.contributor.daisngid25404
dc.contributor.daisngid19357
dc.contributor.daisngid74443
dc.contributor.daisngid106289
dc.contributor.daisngid276771
dc.contributor.daisngid78038
dc.contributor.daisngid34937322
dc.contributor.daisngid246378
dc.contributor.daisngid28836
dc.contributor.daisngid9921613
dc.contributor.daisngid1132156
dc.contributor.daisngid31459758
dc.contributor.daisngid167315
dc.contributor.wosstandardWOS:Hernandez-Alonso, P
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.contributor.wosstandardWOS:Ruiz-Canela, M
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Basora, J
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Munoz, MA
dc.contributor.wosstandardWOS:Buil-Cosiales, P
dc.contributor.wosstandardWOS:Saiz, C
dc.contributor.wosstandardWOS:Bullo, M
dc.date.coverdateAbril 2016
dc.identifier.ulpgces
dc.description.sjr1,619
dc.description.jcr4,548
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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