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Title: Constant infusion transpulmonary thermodilution for the assessment of cardiac output in exercising humans
Authors: Calbet, J. A. L. 
Mortensen, S.P.
Munch, G.D.W.
Curtelin, D.
Boushel, R.
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Arm exercise
Blood flow
Cardiac output
Humans, et al
Issue Date: 2016
Journal: Scandinavian Journal of Medicine and Science in Sports 
Abstract: To determine the accuracy and precision of constant infusion transpulmonary thermodilution cardiac output (CITT-Q) assessment during exercise in humans, using indocyanine green (ICG) dilution and bolus transpulmonary thermodilution (BTD) as reference methods, cardiac output (Q) was determined at rest and during incremental one- and two-legged pedaling on a cycle ergometer, and combined arm cranking with leg pedaling to exhaustion in 15 healthy men. Continuous infusions of iced saline in the femoral vein (n=41) or simultaneously in the femoral and axillary (n=66) veins with determination of temperature in the femoral artery were used for CITT-Q assessment. CITT-Q was linearly related to ICG-Q (r=0.82, CITT-Q=0.876×ICG-Q+3.638, P<0.001; limits of agreement ranging from -1.43 to 3.07L/min) and BTD-Q (r=0.91, CITT-Q=0.822×BTD+4.481L/min, P<0.001; limits of agreement ranging from -1.01 to 2.63L/min). Compared with ICG-Q and BTD-Q, CITT-Q overestimated cardiac output by 1.6L/min (≈10% of the mean ICG and BTD-Q values, P<0.05). For Q between 20 and 28L/min, we estimated an overestimation <5%. The coefficient of variation of 23 repeated CITT-Q measurements was 6.0% (CI: 6.1-11.1%). In conclusion, cardiac output can be precisely and accurately determined with constant infusion transpulmonary thermodilution in exercising humans.
ISSN: 0905-7188
DOI: 10.1111/sms.12473
Source: Scandinavian Journal Of Medicine & Science In Sports[ISSN 0905-7188],v. 26 (5), p. 518-527
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