Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52380
Title: Immunohistochemical expression of progesterone receptors, growth hormone and insulin growth factor-I in feline fibroadenomatous change
Authors: Ordás, J.
Millán, Y.
de los Monteros, A. Espinosa 
Reymundo, C.
de las Mulas, J. Martín
Keywords: Canine Mammary Tissue
Gland
Tumors
Complex
Dog, et al
Issue Date: 2004
Publisher: 0034-5288
Journal: Research in Veterinary Science 
Abstract: The immunohistochemical expression, tissue-specific and cell-specific distribution patterns of progesterone receptors (PR), growth hormone (GH) and insulin growth factor-I (IGF-I) have been studied in 22 cases of feline fibroadenomatous change (FFAC). PR and GH were detected in all cases and were distributed homogeneously throughout the lesion, while lGF-I was detected in 77% of the cases at the site of ductal budding. The simultaneous expression of PR, GH and IGF-I was detected in epithelial cells in 14 of 22 cases while PR and GH expression only was detected in epithelial cells in 11 cases. Cases that expressed GH and IGF-I without PR expression in the stroma were the most numerous. Double immunohistochemical staining showed the co-localisation of PR and GH in a subset of ductal epithelial cells located between basal/myoepithelial and luminal cells (probably undifferentiated stem cells). These results suggest that ligand-activated progesterone receptors may induce the local synthesis of GH which in turn may exert its proliferative action directly and also indirectly through the production of other growth factors, such as IGF-I, in an autocrine/paracrine manner. (C) 2004 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/52380
ISSN: 0034-5288
DOI: 10.1016/j.rvsc.2003.11.006
Source: Research in Veterinary Science[ISSN 0034-5288],v. 76, p. 227-233
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