Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52380
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dc.contributor.authorOrdás, J.
dc.contributor.authorMillán, Y.
dc.contributor.authorde los Monteros, A. Espinosa
dc.contributor.authorReymundo, C.
dc.contributor.authorde las Mulas, J. Martín
dc.date.accessioned2018-11-25T19:51:00Z-
dc.date.available2018-11-25T19:51:00Z-
dc.date.issued2004
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/10553/52380-
dc.description.abstractThe immunohistochemical expression, tissue-specific and cell-specific distribution patterns of progesterone receptors (PR), growth hormone (GH) and insulin growth factor-I (IGF-I) have been studied in 22 cases of feline fibroadenomatous change (FFAC). PR and GH were detected in all cases and were distributed homogeneously throughout the lesion, while lGF-I was detected in 77% of the cases at the site of ductal budding. The simultaneous expression of PR, GH and IGF-I was detected in epithelial cells in 14 of 22 cases while PR and GH expression only was detected in epithelial cells in 11 cases. Cases that expressed GH and IGF-I without PR expression in the stroma were the most numerous. Double immunohistochemical staining showed the co-localisation of PR and GH in a subset of ductal epithelial cells located between basal/myoepithelial and luminal cells (probably undifferentiated stem cells). These results suggest that ligand-activated progesterone receptors may induce the local synthesis of GH which in turn may exert its proliferative action directly and also indirectly through the production of other growth factors, such as IGF-I, in an autocrine/paracrine manner. (C) 2004 Elsevier Ltd. All rights reserved.
dc.publisher0034-5288
dc.relation.ispartofResearch in Veterinary Science
dc.sourceResearch in Veterinary Science[ISSN 0034-5288],v. 76, p. 227-233
dc.subject.otherCanine Mammary Tissue
dc.subject.otherGland
dc.subject.otherTumors
dc.subject.otherComplex
dc.subject.otherDog
dc.subject.otherHypertrophy
dc.subject.otherEstrogen
dc.subject.otherAcid
dc.subject.otherCats
dc.titleImmunohistochemical expression of progesterone receptors, growth hormone and insulin growth factor-I in feline fibroadenomatous change
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.rvsc.2003.11.006
dc.identifier.scopus1842737751
dc.identifier.isi000220755900010
dc.contributor.authorscopusid7004050766
dc.contributor.authorscopusid6603640503
dc.contributor.authorscopusid8846556600
dc.contributor.authorscopusid6602625041
dc.contributor.authorscopusid55666702000
dc.description.lastpage233
dc.description.firstpage227
dc.relation.volume76
dc.type2Artículoes
dc.contributor.daisngid3386953
dc.contributor.daisngid619515
dc.contributor.daisngid700159
dc.contributor.daisngid1431295
dc.contributor.daisngid407245
dc.contributor.wosstandardWOS:Ordas, J
dc.contributor.wosstandardWOS:Millan, Y
dc.contributor.wosstandardWOS:de los Monteros, AE
dc.contributor.wosstandardWOS:Reymundo, C
dc.contributor.wosstandardWOS:de las Mulas, JM
dc.date.coverdateEnero 2004
dc.identifier.ulpgces
dc.description.jcr1,153
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7736-3139-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameEspinosa De Los Monteros Y Zayas, Antonio-
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