Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51935
Title: Effects of fibrin on the integration hydroxyapatite coating implants: Experimental study in a rabbit model
Authors: Morales, M.
Navarro, R.
Almenara, M.
Medina, J. M.
Melian, C. 
Gutierrez, C 
Keywords: Osteogenic Response
Long-Term
Bone
Sealant
Dogs, et al
Issue Date: 2002
Publisher: 0939-8600
Journal: Journal of Experimental Animal Science 
Abstract: The purpose of this study was to investigate the effects of the addition of fibrin (SAF) to titanium alloy implants coated with hydroxyapatite (HAP) on osteogenesis in rabbits. A titanium (Ti) alloy implant was inserted into the femoral neck of twenty-four adult rabbits. Six rabbits were included on each of the following groups: Ti control, HAP-coated Ti Module, HAP-coated Ti nodule with added fibrin glue and Ti module also with added fibrin glue. After seven weeks, bone growth was examined radiographically and by histo-morphometry. The SAF/HAP mixture did caused to a significant increase in bone growth compared to the other groups. The addition of fibrin did not result in an increase in new-bone growth and increase the formation of fibrous tissue in contact with the implant. We concluded that SAF did not demonstrate osteoinductive properties.
URI: http://hdl.handle.net/10553/51935
ISSN: 0939-8600
Source: Journal Of Experimental Animal Science[ISSN 0939-8600],v. 42 (2), p. 102-112
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