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Title: Should the Presence of Metastatic Para-Aortic Lymph Nodes in Locally Advanced Cervical Cancer Lead to More Aggressive Treatment Strategies?
Authors: Benito, Virginia
Carballo Rastrilla, Sonia 
Silva, Patricia
Esparza, Miriam
Arencibia, Octavio
Federico, Mario
Andújar, Miguel 
Mori, Marta
Medina Ramos, Norberto Fidel 
Lubrano, Amina
UNESCO Clasification: 32 Ciencias médicas
320101 Oncología
320108 Ginecología
Keywords: Chemoradiotherapy
Extraperitoneal para-aortic lymphadenectomy
Locally advanced cervical cancer
Metastatic para-aortic nodes
Survival rate
Issue Date: 2017
Journal: Journal of Minimally Invasive Gynecology 
Abstract: Study Objective To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic para-aortic lymphadenectomy (LPL) as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic para-aortic lymph nodes (PLNs). Design Retrospective study conducted on demographic data, pathologic and surgical findings, complications, and disease status recorded for LACC patients undergoing LPL during the period 2009 to 2015. Setting Department of Gynecologic Oncology of the Complejo Hospitalario Universitario Insular-Materno Infantil, Canary Islands, Spain (Canadian Task Force Classification II-3). Patients Women with LACC undergoing pretherapeutic LPL. All patients were treated with definitive chemoradiotherapy after surgery, and those with metastatic PLN received extended lumboaortic radiation therapy. Interventions Survival analysis was performed with the Kaplan-Meier method. Statistical significance was considered for p <.05. Measurements and Main Results The study included 139 patients. The median age was 48 years (range, 28–73). The most frequent histologic type was squamous cell carcinoma (77%), and the most frequent 2009 FIGO stage was IIB (48.2%). LPL identified metastatic PLN in 18.7% of patients (n = 26). The mean overall survival for the whole population, after 23 months of follow-up, was 68.2 months (95% CI, 63–73.4). For patients without para-aortic metastases, the mean survival time was 76.9 months (95% CI, 70.3–80.4), whereas for patients with positive PLNs the median survival time was 21 months (95% CI, 6.1–35.9; p <.0001). A logistic regression analysis revealed that the presence of metastatic PLNs and tumor size (>5 cm) were both independent risk factors for poor survival (OR, 117.5; 95% CI, 11.6–990.2; p <.0001, and OR, 21.5; 95% CI, 2–230.3; p = .01, respectively). Conclusion LACC patients with metastatic PLNs had a poor prognosis and low survival rate. We postulate that this finding could be accounted for by the presence of hidden systemic disease and high recurrence rate after therapy. Efforts should be made to improve available therapeutic strategies for this particular subgroup of patients.
ISSN: 1553-4650
DOI: 10.1016/j.jmig.2017.01.016
Source: Journal of Minimally Invasive Gynecology[ISSN 1553-4650],v. 24(4), p. 609-616 (Mayo-junio 2017)
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