Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51080
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dc.contributor.authorBenito, Virginiaen_US
dc.contributor.authorCarballo Rastrilla, Soniaen_US
dc.contributor.authorSilva, Patriciaen_US
dc.contributor.authorEsparza, Miriamen_US
dc.contributor.authorArencibia, Octavioen_US
dc.contributor.authorFederico, Marioen_US
dc.contributor.authorAndújar, Miguelen_US
dc.contributor.authorMori, Martaen_US
dc.contributor.authorMedina Ramos, Norberto Fidelen_US
dc.contributor.authorLubrano, Aminaen_US
dc.date.accessioned2018-11-24T21:14:22Z-
dc.date.available2018-11-24T21:14:22Z-
dc.date.issued2017en_US
dc.identifier.issn1553-4650en_US
dc.identifier.urihttp://hdl.handle.net/10553/51080-
dc.description.abstractStudy Objective To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic para-aortic lymphadenectomy (LPL) as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic para-aortic lymph nodes (PLNs). Design Retrospective study conducted on demographic data, pathologic and surgical findings, complications, and disease status recorded for LACC patients undergoing LPL during the period 2009 to 2015. Setting Department of Gynecologic Oncology of the Complejo Hospitalario Universitario Insular-Materno Infantil, Canary Islands, Spain (Canadian Task Force Classification II-3). Patients Women with LACC undergoing pretherapeutic LPL. All patients were treated with definitive chemoradiotherapy after surgery, and those with metastatic PLN received extended lumboaortic radiation therapy. Interventions Survival analysis was performed with the Kaplan-Meier method. Statistical significance was considered for p <.05. Measurements and Main Results The study included 139 patients. The median age was 48 years (range, 28–73). The most frequent histologic type was squamous cell carcinoma (77%), and the most frequent 2009 FIGO stage was IIB (48.2%). LPL identified metastatic PLN in 18.7% of patients (n = 26). The mean overall survival for the whole population, after 23 months of follow-up, was 68.2 months (95% CI, 63–73.4). For patients without para-aortic metastases, the mean survival time was 76.9 months (95% CI, 70.3–80.4), whereas for patients with positive PLNs the median survival time was 21 months (95% CI, 6.1–35.9; p <.0001). A logistic regression analysis revealed that the presence of metastatic PLNs and tumor size (>5 cm) were both independent risk factors for poor survival (OR, 117.5; 95% CI, 11.6–990.2; p <.0001, and OR, 21.5; 95% CI, 2–230.3; p = .01, respectively). Conclusion LACC patients with metastatic PLNs had a poor prognosis and low survival rate. We postulate that this finding could be accounted for by the presence of hidden systemic disease and high recurrence rate after therapy. Efforts should be made to improve available therapeutic strategies for this particular subgroup of patients.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Minimally Invasive Gynecologyen_US
dc.sourceJournal of Minimally Invasive Gynecology[ISSN 1553-4650],v. 24(4), p. 609-616 (Mayo-junio 2017)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320101 Oncologíaen_US
dc.subject320108 Ginecologíaen_US
dc.subject.otherChemoradiotherapyen_US
dc.subject.otherExtraperitoneal para-aortic lymphadenectomyen_US
dc.subject.otherLocally advanced cervical canceren_US
dc.subject.otherMetastatic para-aortic nodesen_US
dc.subject.otherSurvival rateen_US
dc.titleShould the Presence of Metastatic Para-Aortic Lymph Nodes in Locally Advanced Cervical Cancer Lead to More Aggressive Treatment Strategies?en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jmig.2017.01.016en_US
dc.identifier.scopus85016567866-
dc.contributor.authorscopusid6602699148-
dc.contributor.authorscopusid55555899400-
dc.contributor.authorscopusid57193789081-
dc.contributor.authorscopusid55633333100-
dc.contributor.authorscopusid15126929400-
dc.contributor.authorscopusid55382811900-
dc.contributor.authorscopusid7004631953-
dc.contributor.authorscopusid57193794542-
dc.contributor.authorscopusid7005688828-
dc.contributor.authorscopusid6602879639-
dc.description.lastpage616en_US
dc.identifier.issue4-
dc.description.firstpage609en_US
dc.relation.volume24en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateMayo-junio 2017en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,105-
dc.description.jcr3,061-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-4858-6915-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCarballo Rastrilla, Sonia-
crisitem.author.fullNameAndujar Sanchez,Miguel-
crisitem.author.fullNameMedina Ramos, Norberto Fidel-
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