Please use this identifier to cite or link to this item:
Title: Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter
Authors: Gnaiger, E.
Boushel, R.
Søndergaard, H.
Munch-Andersen, T.
Damsgaard, R.
Hagen, C.
Díez-Sánchez, C.
Ara, I.
Wright-Paradis, C.
Schrauwen, P.
Hesselink, M.
Calbet, J. A. L. 
Christiansen, M.
Helge, J. W.
Saltin, B.
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Brown Adipose-Tissue
Human Mtdna
Haplogroups, et al
Issue Date: 2015
Publisher: 0905-7188
Journal: Scandinavian Journal of Medicine and Science in Sports 
Abstract: During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein‐3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation.
ISSN: 0905-7188
DOI: 10.1111/sms.12612
Source: Scandinavian Journal Of Medicine & Science In Sports[ISSN 0905-7188],v. 25, p. 126-134
Appears in Collections:Artículos
Show full item record


checked on Mar 26, 2023


checked on Oct 2, 2022

Page view(s)

checked on Sep 24, 2022

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.