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Title: Effect of castration on bone mineral metabolism in rats
Authors: González Rodríguez, M. D.
Sosa Henríquez, M. 
Limiñana Cañal, Jose Maria 
Betancor León, P.
UNESCO Clasification: 3201 Ciencias clínicas
Keywords: Animal Model
GnRH Antagonist
Issue Date: 1990
Journal: Revista clínica española (Ed. impresa) 
Abstract: We have tried to experimentally determine what effect castration is going to have on rats bone and on the main mineral bone regulatory hormones. Twenty ovariectomized female rats and their age and weight matched controls were used. Parathormone, calcitonin, osteocalcin and serum calcium levels were determined as well as mineral bone content and head of femur density. Castration produces, in rat, a marked decrease in circulating calcitonin, parathormone (PTH) and bone density, with no changes in mineral bone concentration. Finally, castration produces a slight increase in osteocalcin serum levels although without a statistical value.
ISSN: 0014-2565
Source: Revista Clinica Espanola[ISSN 0014-2565],v. 186 (9), p. 436-439, (Mayo 1990)
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