Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50622
Title: Use of confirmatory factor analysis for the identification of new components of the metabolic syndrome: The role of plasminogen activator inhibitor-1 and Haemoglobin A1c
Authors: Boronat, M. 
Saavedra, P.
Varillas, V. F.
Nóvoa, F. J.
Keywords: Panel-Iii Criteria
Insulin-Resistance
Diabetes-Mellitus
Adipose-Tissue
Risk-Factors, et al
Issue Date: 2009
Publisher: 0939-4753
Journal: Nutrition, Metabolism and Cardiovascular Diseases 
Abstract: Background and aim: This study was aimed to identify additional components of metabolic syndrome from a set of cardiovascular risk markers.Methods and results: The homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor, homocysteine, Haemoglobin A1c (HbA1c), and lipoprotein(a) were assessed in a population-based sample of 902 nondiabetic adult subjects. Those biomarkers that were associated with metabolic syndrome were evaluated by multiple regression analysis, along with other traditional cardiovascular risk factors. Confirmatory factor analysis (CFA) was used to test the hypothesis that both the established components of metabolic syndrome and the novel variables identified by the regression analysis were associated with a single underlying factor. HCMA-IR, PAI-1 and HbA1c were the only biomarkers independently related to metabolic syndrome. CFA validated a one-factor model that included these variables. Moreover, the indices of goodness of fit were better for this expanded model than those obtained for a previously validated one-factor model that was restricted to the conventional elements of the syndrome.Conclusions: These findings show that PAI-1 and HbA1c are singularly linked to metabolic syndrome. Their elevation is presumably another manifestation of the same pathophysiological mechanism that underlies the recognized traits of the syndrome. (c) 2008 Elsevier B.V. AR rights reserved.
URI: http://hdl.handle.net/10553/50622
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2008.07.007
Source: Nutrition, Metabolism and Cardiovascular Diseases[ISSN 0939-4753],v. 19, p. 271-276
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

13
checked on Jul 3, 2022

WEB OF SCIENCETM
Citations

14
checked on Jul 3, 2022

Page view(s)

26
checked on May 15, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.