Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50622
DC FieldValueLanguage
dc.contributor.authorBoronat, M.en_US
dc.contributor.authorSaavedra, P.en_US
dc.contributor.authorVarillas, V. F.en_US
dc.contributor.authorNóvoa, F. J.en_US
dc.date.accessioned2018-11-24T17:31:04Z-
dc.date.available2018-11-24T17:31:04Z-
dc.date.issued2009en_US
dc.identifier.issn0939-4753en_US
dc.identifier.urihttp://hdl.handle.net/10553/50622-
dc.description.abstractBackground and aim: This study was aimed to identify additional components of metabolic syndrome from a set of cardiovascular risk markers.Methods and results: The homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor, homocysteine, Haemoglobin A1c (HbA1c), and lipoprotein(a) were assessed in a population-based sample of 902 nondiabetic adult subjects. Those biomarkers that were associated with metabolic syndrome were evaluated by multiple regression analysis, along with other traditional cardiovascular risk factors. Confirmatory factor analysis (CFA) was used to test the hypothesis that both the established components of metabolic syndrome and the novel variables identified by the regression analysis were associated with a single underlying factor. HCMA-IR, PAI-1 and HbA1c were the only biomarkers independently related to metabolic syndrome. CFA validated a one-factor model that included these variables. Moreover, the indices of goodness of fit were better for this expanded model than those obtained for a previously validated one-factor model that was restricted to the conventional elements of the syndrome.Conclusions: These findings show that PAI-1 and HbA1c are singularly linked to metabolic syndrome. Their elevation is presumably another manifestation of the same pathophysiological mechanism that underlies the recognized traits of the syndrome.en_US
dc.languageengen_US
dc.relation.ispartofNutrition, Metabolism and Cardiovascular Diseasesen_US
dc.sourceNutrition, Metabolism and Cardiovascular Diseases[ISSN 0939-4753],v. 19, p. 271-276en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherPanel-Iii Criteriaen_US
dc.subject.otherInsulin-Resistanceen_US
dc.subject.otherDiabetes-Mellitusen_US
dc.subject.otherAdipose-Tissueen_US
dc.subject.otherRisk-Factorsen_US
dc.subject.otherGlucoseen_US
dc.subject.otherMarkersen_US
dc.subject.otherPai-1en_US
dc.subject.otherAtherosclerosisen_US
dc.subject.otherDysfunctionen_US
dc.titleUse of confirmatory factor analysis for the identification of new components of the metabolic syndrome: The role of plasminogen activator inhibitor-1 and Haemoglobin A1cen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.numecd.2008.07.007en_US
dc.identifier.scopus67349210418-
dc.identifier.isi000267141800007-
dc.contributor.authorscopusid7003952293-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid12786819300-
dc.contributor.authorscopusid12786120600-
dc.description.lastpage276en_US
dc.description.firstpage271en_US
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid673494-
dc.contributor.daisngid8838450-
dc.contributor.daisngid5465027-
dc.contributor.daisngid556390-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Boronat, M-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Varillas, VF-
dc.contributor.wosstandardWOS:Novoa, FJ-
dc.date.coverdateMayo 2009en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr3,517-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0001-8535-8543-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBoronat Cortés, Mauro-
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