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http://hdl.handle.net/10553/50579
| Título: | Synthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone group | Autores/as: | González, Antonio G. Hernández Silva, Margarita Padrón, Juan I. León, Francisco Reyes, Eduardo Álvarez-Mon, Melchor Pivel, Juan P. Quintana Aguiar, José Martín Estévez, Francisco Bermejo, Jaime |
Clasificación UNESCO: | 32 Ciencias médicas 2302 Bioquímica |
Palabras clave: | Tumor Inhibitors Myeloma Cells Pharmacokinetics Induction Apoptosis, et al. |
Fecha de publicación: | 2002 | Publicación seriada: | Journal of Medicinal Chemistry | Resumen: | The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods. | URI: | http://hdl.handle.net/10553/50579 | ISSN: | 0022-2623 | DOI: | 10.1021/jm025518n | Fuente: | Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 45 (12), p. 2358-2361 |
| Colección: | Artículos |
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