|Title:||Synthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone group||Authors:||González, Antonio G.
Silva, Margarita Hernández
Padrón, Juan I.
Pivel, Juan P.
Apoptosis, et al
|Issue Date:||2002||Publisher:||0022-2623||Journal:||Journal of Medicinal Chemistry||Abstract:||The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.||URI:||http://hdl.handle.net/10553/50579||ISSN:||0022-2623||DOI:||10.1021/jm025518n||Source:||Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 45 (12), p. 2358-2361|
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