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Title: Synthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone group
Authors: González, Antonio G.
Hernández Silva, Margarita
Padrón, Juan I.
León, Francisco
Reyes, Eduardo
Álvarez-Mon, Melchor
Pivel, Juan P.
Quintana Aguiar, José Martín 
Estévez, Francisco 
Bermejo, Jaime
UNESCO Clasification: 32 Ciencias médicas
2302 Bioquímica
Keywords: Tumor Inhibitors
Myeloma Cells
Apoptosis, et al
Issue Date: 2002
Journal: Journal of Medicinal Chemistry 
Abstract: The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.
ISSN: 0022-2623
DOI: 10.1021/jm025518n
Source: Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 45 (12), p. 2358-2361
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