Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50579
DC FieldValueLanguage
dc.contributor.authorGonzález, Antonio G.en_US
dc.contributor.authorSilva, Margarita Hernándezen_US
dc.contributor.authorPadrón, Juan I.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorReyes, Eduardoen_US
dc.contributor.authorÁlvarez-Mon, Melchoren_US
dc.contributor.authorPivel, Juan P.en_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherPadron, Juan-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:09:01Z-
dc.date.available2018-11-24T17:09:01Z-
dc.date.issued2002en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10553/50579-
dc.description.abstractThe biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.en_US
dc.languageengen_US
dc.publisher0022-2623-
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 45 (12), p. 2358-2361en_US
dc.subject.otherTumor Inhibitorsen_US
dc.subject.otherMyeloma Cellsen_US
dc.subject.otherPharmacokineticsen_US
dc.subject.otherInductionen_US
dc.subject.otherApoptosisen_US
dc.subject.otherInversionen_US
dc.subject.otherImexonen_US
dc.subject.otherGrowthen_US
dc.subject.otherDeathen_US
dc.titleSynthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone groupen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm025518nen_US
dc.identifier.scopus0037030646-
dc.identifier.isi000175957700004-
dcterms.isPartOfJournal Of Medicinal Chemistry-
dcterms.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 45 (12), p. 2358-2361-
dc.contributor.authorscopusid56387707800-
dc.contributor.authorscopusid7403410250-
dc.contributor.authorscopusid7003856519-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid35492897800-
dc.contributor.authorscopusid7004340382-
dc.contributor.authorscopusid6701382830-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage2361en_US
dc.identifier.issue12-
dc.description.firstpage2358en_US
dc.relation.volume45en_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000175957700004-
dc.contributor.daisngid914093-
dc.contributor.daisngid8582629-
dc.contributor.daisngid15692786-
dc.contributor.daisngid618078-
dc.contributor.daisngid136703-
dc.contributor.daisngid11720307-
dc.contributor.daisngid5697379-
dc.contributor.daisngid125745-
dc.contributor.daisngid905700-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.description.notasThis research was supported in part by FEDER Grant 1FD1997-1831 (J.B.B), in part by the Fondo de Investigaciones Sanitarias (FIS) Grant 00/0806 (M.A and E.R), and in part by Dirección General de Universidades e Investigación del Gobierno de Canarias Grant 1999/156 (F.E. and J.Q.). M.H.S. thanks the Universidad del Bio-Bio (Chile) for a predoctoral fellowship.en_US
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDI-7660-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Gonzalez, AG-
dc.contributor.wosstandardWOS:Silva, MH-
dc.contributor.wosstandardWOS:Padron, JI-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Reyes, E-
dc.contributor.wosstandardWOS:Alvarez-Mon, M-
dc.contributor.wosstandardWOS:Pivel, JP-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateJunio 2002en_US
dc.identifier.ulpgcen_US
dc.description.jcr4,566
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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