|Title:||Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl-4-butanolides in relation to PGE(2)||Authors:||Miranda, Pedro O.
Garcia, Candelaria I.
Padrón, Juan I.
Pivel, Juan P.
|UNESCO Clasification:||32 Ciencias médicas
230207 Química clínica
Hl-60 Cells, et al
|Issue Date:||2004||Journal:||Journal of Medicinal Chemistry||Abstract:||Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [3H]-PGE2 binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE 2. Compound 9 increases c-fos mRNA level as does PGE2 and antagonizes TPA-induced terminal differentiation.||URI:||http://hdl.handle.net/10553/50576||ISSN:||0022-2623||DOI:||10.1021/jm034216y||Source:||Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295 (Enero 2004)|
|Appears in Collections:||Artículos|
checked on Mar 26, 2023
WEB OF SCIENCETM
checked on Oct 2, 2022
checked on Sep 24, 2022
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.