Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50576
Title: Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl-4-butanolides in relation to PGE(2)
Authors: Miranda, Pedro O.
Estévez, Francisco 
Quintana, José
Garcia, Candelaria I.
Brouard Martín,Ignacio 
Padrón, Juan I.
Pivel, Juan P.
Bermejo, Jaime
UNESCO Clasification: 32 Ciencias médicas
230207 Química clínica
Keywords: Protein-Kinase-C
Prostaglandin E(2)
3T3 Fibroblasts
Gene-Expression
Hl-60 Cells, et al
Issue Date: 2004
Journal: Journal of Medicinal Chemistry 
Abstract: Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [3H]-PGE2 binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE 2. Compound 9 increases c-fos mRNA level as does PGE2 and antagonizes TPA-induced terminal differentiation.
URI: http://hdl.handle.net/10553/50576
ISSN: 0022-2623
DOI: 10.1021/jm034216y
Source: Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295 (Enero 2004)
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