1. accedaCRIS
  2. Publicaciones
  3. Artículos
Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50576
Campo DC Valoridioma
dc.contributor.authorMiranda, Pedro O.en_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorGarcia, Candelaria I.en_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorPadrón, Juan I.en_US
dc.contributor.authorPivel, Juan P.en_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherPadron, Juan-
dc.contributor.otherMiranda Chinea, Pedro Oswaldo-
dc.date.accessioned2018-11-24T17:07:35Z-
dc.date.available2018-11-24T17:07:35Z-
dc.date.issued2004en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10553/50576-
dc.description.abstractCompounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [3H]-PGE2 binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE 2. Compound 9 increases c-fos mRNA level as does PGE2 and antagonizes TPA-induced terminal differentiation.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295 (Enero 2004)en_US
dc.subject32 Ciencias médicasen_US
dc.subject230207 Química clínicaen_US
dc.subject.otherProtein-Kinase-Cen_US
dc.subject.otherProstaglandin E(2)en_US
dc.subject.other3T3 Fibroblastsen_US
dc.subject.otherGene-Expressionen_US
dc.subject.otherHl-60 Cellsen_US
dc.subject.otherAciden_US
dc.subject.otherDifferentiationen_US
dc.subject.otherFosen_US
dc.subject.otherLactonesen_US
dc.subject.otherGrowthen_US
dc.titleEnantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl-4-butanolides in relation to PGE(2)en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm034216yen_US
dc.identifier.scopus0346333098-
dc.identifier.isi000187941600004-
dcterms.isPartOfJournal Of Medicinal Chemistry-
dcterms.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295-
dc.contributor.authorscopusid55765536200-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid18934373300-
dc.contributor.authorscopusid57212429765-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid7003856519-
dc.contributor.authorscopusid6701382830-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage295en_US
dc.identifier.issue2-
dc.description.firstpage292en_US
dc.relation.volume47en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000187941600004-
dc.contributor.daisngid1268140-
dc.contributor.daisngid384944-
dc.contributor.daisngid128315-
dc.contributor.daisngid2766566-
dc.contributor.daisngid31417939-
dc.contributor.daisngid657275-
dc.contributor.daisngid618078-
dc.contributor.daisngid905700-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDI-7660-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages4en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Miranda, PO-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Garcia, CI-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Padron, JI-
dc.contributor.wosstandardWOS:Pivel, JP-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateEnero 2004en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr5,076-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameBrouard Martín,Ignacio-
Colección:Artículos
Vista resumida

Citas SCOPUSTM   

13
actualizado el 21-abr-2024

Citas de WEB OF SCIENCETM
Citations

13
actualizado el 25-feb-2024

Visitas

39
actualizado el 23-dic-2023

Google ScholarTM

Verifica

Altmetric


Comparte


Exporta metadatos


Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.