1. accedaCRIS
  2. Publicaciones
  3. Artículos
Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50576
DC FieldValueLanguage
dc.contributor.authorMiranda, Pedro O.en_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorGarcia, Candelaria I.en_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorPadrón, Juan I.en_US
dc.contributor.authorPivel, Juan P.en_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherPadron, Juan-
dc.contributor.otherMiranda Chinea, Pedro Oswaldo-
dc.date.accessioned2018-11-24T17:07:35Z-
dc.date.available2018-11-24T17:07:35Z-
dc.date.issued2004en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10553/50576-
dc.description.abstractCompounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [3H]-PGE2 binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE 2. Compound 9 increases c-fos mRNA level as does PGE2 and antagonizes TPA-induced terminal differentiation.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295 (Enero 2004)en_US
dc.subject32 Ciencias médicasen_US
dc.subject230207 Química clínicaen_US
dc.subject.otherProtein-Kinase-Cen_US
dc.subject.otherProstaglandin E(2)en_US
dc.subject.other3T3 Fibroblastsen_US
dc.subject.otherGene-Expressionen_US
dc.subject.otherHl-60 Cellsen_US
dc.subject.otherAciden_US
dc.subject.otherDifferentiationen_US
dc.subject.otherFosen_US
dc.subject.otherLactonesen_US
dc.subject.otherGrowthen_US
dc.titleEnantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl-4-butanolides in relation to PGE(2)en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm034216yen_US
dc.identifier.scopus0346333098-
dc.identifier.isi000187941600004-
dcterms.isPartOfJournal Of Medicinal Chemistry-
dcterms.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 47 (2), p. 292-295-
dc.contributor.authorscopusid55765536200-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid18934373300-
dc.contributor.authorscopusid57212429765-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid7003856519-
dc.contributor.authorscopusid6701382830-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage295en_US
dc.identifier.issue2-
dc.description.firstpage292en_US
dc.relation.volume47en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000187941600004-
dc.contributor.daisngid1268140-
dc.contributor.daisngid384944-
dc.contributor.daisngid128315-
dc.contributor.daisngid2766566-
dc.contributor.daisngid31417939-
dc.contributor.daisngid657275-
dc.contributor.daisngid618078-
dc.contributor.daisngid905700-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDI-7660-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages4en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Miranda, PO-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Garcia, CI-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Padron, JI-
dc.contributor.wosstandardWOS:Pivel, JP-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateEnero 2004en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr5,076-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameBrouard Martín, Ignacio-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

13
checked on Mar 30, 2025

WEB OF SCIENCETM
Citations

13
checked on Mar 30, 2025

Page view(s)

71
checked on Jun 29, 2024

Google ScholarTM

Check

Altmetric


Share


Export metadata


Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.