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Title: Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities
Authors: Triana, Jorge
López, Mariana
Pérez, Francisco J. 
González-Platas, Javier
Quintana, J 
Estevez, F 
León, Francisco
Bermejo, Jaime
Keywords: Myeloid-Leukemia Cells
Germacranolides, et al
Issue Date: 2005
Publisher: 0163-3864
Project: Nuevos Compuestos Antileucémicos 
Journal: Journal of Natural Products 
Abstract: Thirteen new sesquiterpenes, pulicanadiene A (1), B (2), and C (3), pulicanone (4), pulicanol (5), pulicanarals A (6), B (7), and C (8), pulicanadienals A (9) and B (10), pulicanadienol (11), and pulioplopanones A (12) and B (13), and seven known compounds, stigmasterol, ergosterol peroxide, calenduladiol, 7,4'-di-O-methyldihydrokaempferol, 5,7-dihydroxy-3,3',4'-trimethoxyflavone, dihydroquercetin 7,3'-dimethyl ether, and 6,15 alpha-epoxy-1 beta,4 beta-dihydroxyeudesmane, were isolated from Pulicaria canariensis. Compound 4a showed cytotoxicity on the human myeloid leukemia cell line HL-60. The cytotoxicity was caused by induction of apoptosis as determined by microscopy of nuclear changes, activation of caspases, and the cleavage of poly(ADP-ribose) polymerase-1.
ISSN: 0163-3864
DOI: 10.1021/np0496183
Source: Journal Of Natural Products[ISSN 0163-3864],v. 68 (4), p. 523-531
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