Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50570
DC FieldValueLanguage
dc.contributor.authorTriana, Jorgeen_US
dc.contributor.authorLópez, Marianaen_US
dc.contributor.authorPérez, Francisco J.en_US
dc.contributor.authorGonzález-Platas, Javieren_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorEstevez, Fen_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherGonzalez-Platas, Javier-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:04:49Z-
dc.date.available2018-11-24T17:04:49Z-
dc.date.issued2005en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10553/50570-
dc.description.abstractThirteen new sesquiterpenes, pulicanadiene A (1), B (2), and C (3), pulicanone (4), pulicanol (5), pulicanarals A (6), B (7), and C (8), pulicanadienals A (9) and B (10), pulicanadienol (11), and pulioplopanones A (12) and B (13), and seven known compounds, stigmasterol, ergosterol peroxide, calenduladiol, 7,4'-di-O-methyldihydrokaempferol, 5,7-dihydroxy-3,3',4'-trimethoxyflavone, dihydroquercetin 7,3'-dimethyl ether, and 6,15 alpha-epoxy-1 beta,4 beta-dihydroxyeudesmane, were isolated from Pulicaria canariensis. Compound 4a showed cytotoxicity on the human myeloid leukemia cell line HL-60. The cytotoxicity was caused by induction of apoptosis as determined by microscopy of nuclear changes, activation of caspases, and the cleavage of poly(ADP-ribose) polymerase-1.en_US
dc.languagespaen_US
dc.publisher0163-3864
dc.relationNuevos Compuestos Antileucémicosen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal Of Natural Products[ISSN 0163-3864],v. 68 (4), p. 523-531en_US
dc.subject.otherMyeloid-Leukemia Cells
dc.subject.otherConstituents
dc.subject.otherLactones
dc.subject.otherDihydroflavonols
dc.subject.otherGermacranolides
dc.subject.otherDerivatives
dc.subject.otherDysenterica
dc.subject.otherTerpenoids
dc.subject.otherApoptosis
dc.titleSesquiterpenoids from Pulicaria canariensis and their cytotoxic activitiesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/np0496183en_US
dc.identifier.scopus17844370795-
dc.identifier.isi000228677000009-
dcterms.isPartOfJournal Of Natural Products
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 68 (4), p. 523-531
dc.contributor.authorscopusid6602859915-
dc.contributor.authorscopusid22985994700-
dc.contributor.authorscopusid57197103237-
dc.contributor.authorscopusid6602697986-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage531en_US
dc.description.firstpage523en_US
dc.relation.volume68en_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000228677000009-
dc.contributor.daisngid1400733-
dc.contributor.daisngid5158464-
dc.contributor.daisngid34494-
dc.contributor.daisngid34895917-
dc.contributor.daisngid424768-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid136703-
dc.contributor.daisngid5695465-
dc.contributor.daisngid29603-
dc.identifier.investigatorRIDI-1937-2015-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Triana, J-
dc.contributor.wosstandardWOS:Lopez, M-
dc.contributor.wosstandardWOS:Perez, FJ-
dc.contributor.wosstandardWOS:Gonzalez-Platas, J-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateAbril 2005en_US
dc.identifier.ulpgces
dc.description.jcr2,267
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptGIR Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptGIR Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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