Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/50570
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Triana, Jorge | en_US |
dc.contributor.author | Lopez Sanchez,Mariana | en_US |
dc.contributor.author | Pérez, Francisco J. | en_US |
dc.contributor.author | González-Platas, Javier | en_US |
dc.contributor.author | Quintana, J | en_US |
dc.contributor.author | Estevez, F | en_US |
dc.contributor.author | León, Francisco | en_US |
dc.contributor.author | Bermejo, Jaime | en_US |
dc.contributor.other | Gonzalez-Platas, Javier | - |
dc.contributor.other | Quintana, Jose | - |
dc.contributor.other | Estevez, Francisco | - |
dc.contributor.other | Leon, Francisco | - |
dc.date.accessioned | 2018-11-24T17:04:49Z | - |
dc.date.available | 2018-11-24T17:04:49Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.issn | 0163-3864 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/50570 | - |
dc.description.abstract | Thirteen new sesquiterpenes, pulicanadiene A (1), B (2), and C (3), pulicanone (4), pulicanol (5), pulicanarals A (6), B (7), and C (8), pulicanadienals A (9) and B (10), pulicanadienol (11), and pulioplopanones A (12) and B (13), and seven known compounds, stigmasterol, ergosterol peroxide, calenduladiol, 7,4'-di-O-methyldihydrokaempferol, 5,7-dihydroxy-3,3',4'-trimethoxyflavone, dihydroquercetin 7,3'-dimethyl ether, and 6,15 alpha-epoxy-1 beta,4 beta-dihydroxyeudesmane, were isolated from Pulicaria canariensis. Compound 4a showed cytotoxicity on the human myeloid leukemia cell line HL-60. The cytotoxicity was caused by induction of apoptosis as determined by microscopy of nuclear changes, activation of caspases, and the cleavage of poly(ADP-ribose) polymerase-1. | en_US |
dc.language | eng | en_US |
dc.relation | Nuevos Compuestos Antileucémicos | en_US |
dc.relation.ispartof | Journal of Natural Products | en_US |
dc.source | Journal Of Natural Products[ISSN 0163-3864],v. 68 (4), p. 523-531 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3209 Farmacología | en_US |
dc.subject.other | Myeloid-Leukemia Cells | en_US |
dc.subject.other | Constituents | en_US |
dc.subject.other | Lactones | en_US |
dc.subject.other | Dihydroflavonols | en_US |
dc.subject.other | Germacranolides | en_US |
dc.subject.other | Derivatives | en_US |
dc.subject.other | Dysenterica | en_US |
dc.subject.other | Terpenoids | en_US |
dc.subject.other | Apoptosis | en_US |
dc.title | Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1021/np0496183 | en_US |
dc.identifier.scopus | 17844370795 | - |
dc.identifier.isi | 000228677000009 | - |
dcterms.isPartOf | Journal Of Natural Products | - |
dcterms.source | Journal Of Natural Products[ISSN 0163-3864],v. 68 (4), p. 523-531 | - |
dc.contributor.authorscopusid | 6602859915 | - |
dc.contributor.authorscopusid | 22985994700 | - |
dc.contributor.authorscopusid | 57197103237 | - |
dc.contributor.authorscopusid | 6602697986 | - |
dc.contributor.authorscopusid | 8681043500 | - |
dc.contributor.authorscopusid | 7003810011 | - |
dc.contributor.authorscopusid | 7005039451 | - |
dc.contributor.authorscopusid | 7101636723 | - |
dc.description.lastpage | 531 | en_US |
dc.description.firstpage | 523 | en_US |
dc.relation.volume | 68 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000228677000009 | - |
dc.contributor.daisngid | 1400733 | - |
dc.contributor.daisngid | 5158464 | - |
dc.contributor.daisngid | 34494 | - |
dc.contributor.daisngid | 34895917 | - |
dc.contributor.daisngid | 424768 | - |
dc.contributor.daisngid | 128315 | - |
dc.contributor.daisngid | 384944 | - |
dc.contributor.daisngid | 136703 | - |
dc.contributor.daisngid | 5695465 | - |
dc.contributor.daisngid | 29603 | - |
dc.identifier.investigatorRID | I-1937-2015 | - |
dc.identifier.investigatorRID | K-5709-2014 | - |
dc.identifier.investigatorRID | K-5125-2014 | - |
dc.identifier.investigatorRID | No ID | - |
dc.description.numberofpages | 9 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Triana, J | - |
dc.contributor.wosstandard | WOS:Lopez, M | - |
dc.contributor.wosstandard | WOS:Perez, FJ | - |
dc.contributor.wosstandard | WOS:Gonzalez-Platas, J | - |
dc.contributor.wosstandard | WOS:Quintana, J | - |
dc.contributor.wosstandard | WOS:Estevez, F | - |
dc.contributor.wosstandard | WOS:Leon, F | - |
dc.contributor.wosstandard | WOS:Bermejo, J | - |
dc.date.coverdate | Abril 2005 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 2,267 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.orcid | 0000-0001-8225-4538 | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Lopez Sanchez,Mariana | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
crisitem.author.fullName | Quintana Aguiar, José Martín | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
crisitem.project.principalinvestigator | Estévez Rosas, Francisco Jesús | - |
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