Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50564
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dc.contributor.authorLeón, Francisco
dc.contributor.authorBrouard, Ignacio
dc.contributor.authorTorres, Fernando
dc.contributor.authorQuintana, Jose
dc.contributor.authorRivera, Augusto
dc.contributor.authorEstevez, Francisco
dc.contributor.authorBermejo, Jaime
dc.contributor.otherTorres Andon, Fernando
dc.contributor.otherQuintana, Jose
dc.contributor.otherBrouard, Ignacio
dc.contributor.otherEstevez, Francisco
dc.contributor.otherLeon, Francisco
dc.date.accessioned2018-11-24T17:01:58Z-
dc.date.available2018-11-24T17:01:58Z-
dc.date.issued2008
dc.identifier.issn1612-1872
dc.identifier.urihttp://hdl.handle.net/10553/50564-
dc.description.abstractA new phytosphingosine-type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. E GRAY, along with ten known compounds: ergosta-4,6,8(14),22-tetraen-3-one, ergosterol, ergosterol peroxide, suillin, (E)-3,4,5-trimethoxycinnamic alcohol, 5 alpha,6 alpha-epoxyergosta-8,22-diene-3 beta,7 beta-diol, (R)-1-palmitoylglycerol, ergosta-7,9(11),22-triene-3 beta,5 alpha,6 beta-triol, cerevisterol, and 4-hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass-spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK-MEL-1. Both drugs showed IC50 values of ca. 10 mu m after 72 h of exposure.
dc.publisher1612-1872
dc.relation.ispartofChemistry and Biodiversity
dc.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125
dc.subject.otherFungi
dc.subject.otherConstituents
dc.subject.otherGranulatus
dc.subject.otherAcids
dc.titleA new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1002/cbdv.200890002
dc.identifier.scopus38849104877
dc.identifier.isi000252838300009
dcterms.isPartOfChemistry & Biodiversity
dcterms.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125
dc.contributor.authorscopusid7005039451
dc.contributor.authorscopusid6603470039
dc.contributor.authorscopusid55366045300
dc.contributor.authorscopusid8681043500
dc.contributor.authorscopusid7102211501
dc.contributor.authorscopusid7003810011
dc.contributor.authorscopusid7101636723
dc.description.lastpage125
dc.description.firstpage120
dc.relation.volume5
dc.type2Artículoes
dc.identifier.wosWOS:000252838300009
dc.contributor.daisngid136703
dc.contributor.daisngid657275
dc.contributor.daisngid2952604
dc.contributor.daisngid34941095
dc.contributor.daisngid128315
dc.contributor.daisngid244051
dc.contributor.daisngid384944
dc.contributor.daisngid5695465
dc.identifier.investigatorRIDD-5184-2009
dc.identifier.investigatorRIDK-5709-2014
dc.identifier.investigatorRIDK-5175-2014
dc.identifier.investigatorRIDK-5125-2014
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Leon, F
dc.contributor.wosstandardWOS:Brouard, I
dc.contributor.wosstandardWOS:Torres, F
dc.contributor.wosstandardWOS:Quintana, J
dc.contributor.wosstandardWOS:Rivera, A
dc.contributor.wosstandardWOS:Estevez, F
dc.contributor.wosstandardWOS:Bermejo, J
dc.date.coverdateFebrero 2008
dc.identifier.ulpgces
dc.description.jcr1,659
dc.description.jcrqQ2
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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