Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50564
DC FieldValueLanguage
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorRivera, Augustoen_US
dc.contributor.authorEstevez, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherTorres Andon, Fernando-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:01:58Z-
dc.date.available2018-11-24T17:01:58Z-
dc.date.issued2008en_US
dc.identifier.issn1612-1872en_US
dc.identifier.urihttp://hdl.handle.net/10553/50564-
dc.description.abstractA new phytosphingosine-type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. E GRAY, along with ten known compounds: ergosta-4,6,8(14),22-tetraen-3-one, ergosterol, ergosterol peroxide, suillin, (E)-3,4,5-trimethoxycinnamic alcohol, 5 alpha,6 alpha-epoxyergosta-8,22-diene-3 beta,7 beta-diol, (R)-1-palmitoylglycerol, ergosta-7,9(11),22-triene-3 beta,5 alpha,6 beta-triol, cerevisterol, and 4-hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass-spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK-MEL-1. Both drugs showed IC50 values of ca. 10 mu m after 72 h of exposure.en_US
dc.languageengen_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125 (Febrero 2008)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherFungien_US
dc.subject.otherConstituentsen_US
dc.subject.otherGranulatusen_US
dc.subject.otherAcidsen_US
dc.titleA new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cbdv.200890002en_US
dc.identifier.scopus38849104877-
dc.identifier.isi000252838300009-
dcterms.isPartOfChemistry & Biodiversity-
dcterms.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7102211501-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage125en_US
dc.description.firstpage120en_US
dc.relation.volume5en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000252838300009-
dc.contributor.daisngid136703-
dc.contributor.daisngid657275-
dc.contributor.daisngid2952604-
dc.contributor.daisngid34941095-
dc.contributor.daisngid128315-
dc.contributor.daisngid244051-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDD-5184-2009-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Torres, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Rivera, A-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateFebrero 2008en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,659-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBrouard Martín,Ignacio-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

23
checked on Dec 4, 2022

WEB OF SCIENCETM
Citations

17
checked on Oct 2, 2022

Page view(s)

22
checked on Oct 29, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.