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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50564
DC FieldValueLanguage
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorRivera, Augustoen_US
dc.contributor.authorEstevez, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherTorres Andon, Fernando-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:01:58Z-
dc.date.available2018-11-24T17:01:58Z-
dc.date.issued2008en_US
dc.identifier.issn1612-1872en_US
dc.identifier.urihttp://hdl.handle.net/10553/50564-
dc.description.abstractA new phytosphingosine-type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. E GRAY, along with ten known compounds: ergosta-4,6,8(14),22-tetraen-3-one, ergosterol, ergosterol peroxide, suillin, (E)-3,4,5-trimethoxycinnamic alcohol, 5 alpha,6 alpha-epoxyergosta-8,22-diene-3 beta,7 beta-diol, (R)-1-palmitoylglycerol, ergosta-7,9(11),22-triene-3 beta,5 alpha,6 beta-triol, cerevisterol, and 4-hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass-spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK-MEL-1. Both drugs showed IC50 values of ca. 10 mu m after 72 h of exposure.en_US
dc.languageengen_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125 (Febrero 2008)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherFungien_US
dc.subject.otherConstituentsen_US
dc.subject.otherGranulatusen_US
dc.subject.otherAcidsen_US
dc.titleA new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cbdv.200890002en_US
dc.identifier.scopus38849104877-
dc.identifier.isi000252838300009-
dcterms.isPartOfChemistry & Biodiversity-
dcterms.sourceChemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7102211501-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage125en_US
dc.description.firstpage120en_US
dc.relation.volume5en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000252838300009-
dc.contributor.daisngid136703-
dc.contributor.daisngid657275-
dc.contributor.daisngid2952604-
dc.contributor.daisngid34941095-
dc.contributor.daisngid128315-
dc.contributor.daisngid244051-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDD-5184-2009-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages6en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Torres, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Rivera, A-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateFebrero 2008en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,659-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBrouard Martín, Ignacio-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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