Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50557
Title: Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway
Authors: Burmistrova, Olga
Quintana, Jose 
Díaz, Jesús G.
Estévez, Francisco 
Keywords: Differential Regulation
Specificity
Apoptosis
Issue Date: 2011
Publisher: 0304-3835
Project: Evaluación de Potenciales Compuestos Antileucémicos. 
Journal: Cancer Letters 
Abstract: Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. Here we demonstrate that the flavonoid derivative astragalin heptaacetate (AHA) induces cell death. This was prevented by the non-specific caspase inhibitors z-VAD-fmk and Q-VD-OPH, and reduced by the selective caspase-4 inhibitor z-LEVD-fmk. AHA-induced cell death was found to be: (i) associated with the release of cytochrome c, (ii) suppressed by the overexpression of Bcl-x(L), (iii) amplified by inhibition of extracellular signal-regulated kinases (ERKs) 1/2 and c-jun NH2-terminal kinases/stress activated protein kinases (JNK/SAPK) signaling, and (iv) completely abrogated by the free-radical scavenger N-acetyl-L-cysteine. (C) Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/50557
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2011.05.018
Source: Cancer Letters[ISSN 0304-3835],v. 309, p. 71-77
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