Please use this identifier to cite or link to this item:
Title: Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells
Authors: Marrero, María Teresa
Estévez, Sara
Negrín, Gledy
Quintana, Jose 
López, Mariana
Pérez, Francisco J. 
Triana, Jorge
León, Francisco
Estévez, Francisco 
UNESCO Clasification: 32 Ciencias médicas
2403 Bioquímica
Keywords: Clinical-Implications
Induced Apoptosis
Targeting Death
Decoy Receptors
Cancer, et al
Issue Date: 2012
Project: Evaluación de Potenciales Compuestos Antileucémicos. 
Journal: Biochemical and biophysical research communications (Print) 
Abstract: Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with ayanin diacetate and TRAIL amplified cell death, compared to single treatments. These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer.
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2012.10.017
Source: Biochemical and Biophysical Research Communications[ISSN 0006-291X],v. 428(1), p. 116-120 (Noviembre 2012)
Appears in Collections:Artículos
Show full item record


checked on Nov 20, 2022


checked on Oct 2, 2022

Page view(s)

checked on Oct 29, 2022

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.