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http://hdl.handle.net/10553/50549
Título: | Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells | Autores/as: | Marrero, María Teresa Estévez, Sara Negrín, Gledy Quintana, Jose López, Mariana Pérez, Francisco J. Triana, Jorge León, Francisco Estévez, Francisco |
Clasificación UNESCO: | 32 Ciencias médicas 2403 Bioquímica |
Palabras clave: | Clinical-Implications Induced Apoptosis Targeting Death Decoy Receptors Cancer, et al. |
Fecha de publicación: | 2012 | Proyectos: | Evaluación de Potenciales Compuestos Antileucémicos. | Publicación seriada: | Biochemical and biophysical research communications (Print) | Resumen: | Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with ayanin diacetate and TRAIL amplified cell death, compared to single treatments. These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer. | URI: | http://hdl.handle.net/10553/50549 | ISSN: | 0006-291X | DOI: | 10.1016/j.bbrc.2012.10.017 | Fuente: | Biochemical and Biophysical Research Communications[ISSN 0006-291X],v. 428(1), p. 116-120 (Noviembre 2012) |
Colección: | Artículos |
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