Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50549
DC FieldValueLanguage
dc.contributor.authorMarrero, María Teresaen_US
dc.contributor.authorEstévez, Saraen_US
dc.contributor.authorNegrín, Gledyen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorLópez, Marianaen_US
dc.contributor.authorPérez, Francisco J.en_US
dc.contributor.authorTriana, Jorgeen_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T16:54:49Z-
dc.date.available2018-11-24T16:54:49Z-
dc.date.issued2012en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/50549-
dc.description.abstractHere we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with ayanin diacetate and TRAIL amplified cell death, compared to single treatments. These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.languagespaen_US
dc.publisher0006-291X
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofBiochemical and biophysical research communications (Print)en_US
dc.sourceBiochemical and Biophysical Research Communications[ISSN 0006-291X],v. 428, p. 116-120en_US
dc.subject.otherClinical-Implications
dc.subject.otherInduced Apoptosis
dc.subject.otherTargeting Death
dc.subject.otherDecoy Receptors
dc.subject.otherCancer
dc.subject.otherP53
dc.subject.otherResistance
dc.subject.otherPathway
dc.subject.otherFamily
dc.subject.otherGene
dc.titleAyanin diacetate-induced cell death is amplified by TRAIL in human leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbrc.2012.10.017en_US
dc.identifier.scopus84868379401-
dc.identifier.isi000311523200020-
dcterms.isPartOfBiochemical And Biophysical Research Communications
dcterms.sourceBiochemical And Biophysical Research Communications[ISSN 0006-291X],v. 428 (1), p. 116-120
dc.contributor.authorscopusid55055343200-
dc.contributor.authorscopusid53867837200-
dc.contributor.authorscopusid36094735900-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid22985994700-
dc.contributor.authorscopusid57197103237-
dc.contributor.authorscopusid55946071500-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage120en_US
dc.description.firstpage116en_US
dc.relation.volume428en_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000311523200020-
dc.contributor.daisngid2743847-
dc.contributor.daisngid23115881-
dc.contributor.daisngid6059605-
dc.contributor.daisngid128315-
dc.contributor.daisngid5158464-
dc.contributor.daisngid34494-
dc.contributor.daisngid34895917-
dc.contributor.daisngid1400733-
dc.contributor.daisngid136703-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Marrero, MT-
dc.contributor.wosstandardWOS:EstevezA, S-
dc.contributor.wosstandardWOS:Negrin, G-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Lopez, M-
dc.contributor.wosstandardWOS:Perez, FJ-
dc.contributor.wosstandardWOS:Triana, J-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateNoviembre 2012en_US
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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